Development of tip-enhanced optical spectroscopy for biological applications: a review

Elfick, Alistair P. D.; Downes, Andrew R.; Mouras, Rabah
January 2010
Analytical & Bioanalytical Chemistry;Jan2010, Vol. 396 Issue 1, p45
Academic Journal
Tip-enhanced optical spectroscopy is an approach that holds a good deal of promise for the nanoscale characterisation of matter. Tip-enhanced Raman spectroscopy (TERS) has been demonstrated on a variety of samples: inorganic, organic and biological. Imaging using TERS has been shown for carbon nanotubes due to their high scattering efficiency. There are a number of compelling motivations to consider alternative approaches for biological samples; most importantly, the potential for heat damage of biomolecules and long acquisition times. These issues may be addressed through the development of tip-enhanced coherent anti-Stokes Raman scattering microscopy.


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