Dietary modulation of peroxisome proliferator-activated receptor gamma

Marion-Letellier, R.; Déchelotte, P.; Iacucci, M.; Ghosh, S.
April 2009
Gut;Apr2009, Vol. 58 Issue 4, p585
Academic Journal
Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor that regulates intestinal inflammation. PPARγ is highly expressed in the colon and can be activated by various dietary ligands. A number of fatty acids such as polyunsaturated fatty acids or eicosanoids are considered as endogenous PPARγ activators. Nevertheless, other nutrients such as glutamine, spicy food or flavonoids are also able to activate PPARγ. As PPARγ plays a key role in bacterial induced inflammation, anti-inflammatory properties of probiotics may be mediated through PPARγ. The aims of the present review are to discuss of the potential roles of dietary compounds in modulating intestinal inflammation through PPARγ.


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