Recent advances in coeliac disease genetics

Hunt, Karen A.; van Heel, David A.
April 2009
Gut;Apr2009, Vol. 58 Issue 4, p473
Academic Journal
The article offers information on coeliac disease, which affects around one in 100 individuals in Europe. The disease generates an immune response in the small intestine to fragments of gluten leading to architectural changes in the small intestine which include villous atrophy and an increase in the number of intra-epithelial cells. It mentions the inherited genetic factors affecting the disease aside from the well known environmental factor, the gluten.


Related Articles

  • Modeling of celiac disease immune response and the therapeutic effect of potential drugs. Demin, Oleg O.; Smirnov, Sergey V.; Sokolov, Victor V.; Cucurull-Sanchez, Lourdes; Pichardo-Almarza, Cesar; Victoria Flores, M.; Benson, Neil; Demin, Oleg V. // BMC Systems Biology;2013, Vol. 7 Issue 1, p1 

    Background: Celiac disease (CD) is an autoimmune disorder that occurs in genetically predisposed people and is caused by a reaction to the gluten protein found in wheat, which leads to intestinal villous atrophy. Currently there is no drug for treatment of CD. The only known treatment is...

  • A unified hypothesis of coeliac disease with implications for management of patients. H. J. Cornell; T. Stelmasiak // Amino Acids;Jul2007, Vol. 33 Issue 1, p43 

    Summary.  This mini-review presents the research carried out within the context of two of the main hypotheses of the aetiology of coeliac disease. The enzymopathic hypothesis of the disease has been placed clearly as the underlying deficiency causing increased levels of toxic peptides,...

  • In celiac disease, a subset of autoantibodies against transglutaminase binds toll-like receptor 4 and induces activation of monocytes. Zanoni, Giovanna; Navone, Riccardo; Lunardi, Claudio; Tridente, Giuseppe; Bason, Caterina; Sivori, Simona; Beri, Ruggero; Dolcino, Marzia; Valletta, Enrico; Corrocher, Roberto; Puccetti, Antonio // PLoS Medicine;Sep2006, Vol. 3 Issue 9, pe358 

    Background: Celiac disease is a small intestine inflammatory disorder with multiple organ involvement, sustained by an inappropriate immune response to dietary gluten. Anti-transglutaminase antibodies are a typical serological marker in patients with active disease, and may...

  • Can you learn to tolerate gluten? Le Page, Michael // New Scientist;10/19/2002, Vol. 176 Issue 2365, p21 

    Discusses that people suffering from coeliac disease cannot eat food containing gluten. Problems that arise due to the intake of gluten diets; Role of peptides in triggering an immune response; Treatment of the celiac disease.

  • Non-celiac Gluten Sensitivity. Is it in the Gluten or the Grain? Nijeboer, Petula; Bontkes, Hetty J.; Mulder, Chris J. J.; Bouma, Gerd // Journal of Gastrointestinal & Liver Diseases;Dec2013, Vol. 22 Issue 4, p435 

    Celiac disease is an immune-mediated inflammatory disorder of the small intestine caused by sensitivity to dietary gluten and related proteins in genetically predisposed individuals. Over the past several years, the concept of non-celiac gluten sensitivity (NCGS) has gained significant interest...

  • Vitamin D: The Sunshine Vitamin. Are you getting enough? Harris, Cheryl // GIG Newsletter;Winter2008, Vol. 31 Issue 1, p14 

    The article suggests the importance of vitamin D to people with celiac disease (CD) and gluten intolerance. It cites the various factors that play a role in determining how much vitamin D the body produces from sunlight which include skin pigmentation, age, sunscreen and geographic location. CD...

  • Low-medium resolution HLA-DQ2/DQ8 typing for coeliac disease predisposition analysis by colorimetric assay. Joda, Hamdi; Beni, Valerio; Curnane, Deirdre; Katakis, Ioanis; Alakulppi, Noora; Partanen, Jukka; Lind, Kristina; Strömbom, Linda; O'Sullivan, Ciara // Analytical & Bioanalytical Chemistry;Aug2012, Vol. 404 Issue 2, p807 

    Coeliac disease is an inflammation of the small intestine, occurring in genetically susceptible individuals triggered by the ingestion of gluten. Human Leukocyte Antigens (HLA) DQ2 and DQ8 gene have been identified as key genetic factors in coeliac disease as they are presented in almost 100 %...

  • Activation and Inhibition of Transglutaminase 2 in Mice. Dafik, Laila; Albertelli, Megan; Stamnaes, Jorunn; Sollid, Ludvig M.; Khosla, Chaitan // PLoS ONE;Feb2012, Vol. 7 Issue 2, p1 

    Transglutaminase 2 (TG2) is an allosterically regulated enzyme with transamidating, deamidating and cell signaling activities. It is thought to catalyze sequence-specific deamidation of dietary gluten peptides in the small intestines of celiac disease patients. Because this modification has...

  • Immunoregulatory Pathways Are Active in the Small Intestinal Mucosa of Patients with Potential Celiac Disease. Borrelli, Melissa; Salvati, Virginia M; Maglio, Mariantonia; Zanzi, Delia; Ferrara, Katia; Santagata, Sara; Ponticelli, Domenico; Aitoro, Rosita; Mazzarella, Giuseppe; Lania, Giuliana; Gianfrani, Carmen; Auricchio, Renata; Troncone, Riccardo // American Journal of Gastroenterology;Nov2013, Vol. 108 Issue 11, p1775 

    OBJECTIVES:Potential celiac disease (CD) relates to subjects with a normal small intestinal mucosa who are at increased risk of developing CD as indicated by positive CD-associated serology. The objective of this study was to investigate in the small intestinal mucosa of such patients the state...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics