Conjugation of quantum dots and Fe3O4 on carbon nanotubes for medical diagnosis and treatment

Donglu Shi; Hoon Sung Cho; Huth, Chris; Feng Wang; Zhongyun Dong; Pauletti, Giovanni. M.; Jie Lian; Wei Wang; Guokui Liu; Bud'ko, Sergey L.; Lumin Wang; Ewing, Rodney C.
November 2009
Applied Physics Letters;11/30/2009, Vol. 95 Issue 22, p223702
Academic Journal
Quantum dots (QDs) and Fe3O4 nanoparticles were conjugated onto the surfaces of carbon nanotubes (CNTs) for medical diagnosis and treatment. The nanoassembly was designed to meet the specific needs in cancer in vivo imaging and simultaneous treatment. The key functionalities needed for clinical applications were integrated, including CNT surface functionalization for attachment of biological molecules in targeting, drug storage capabilities, fluorescent emissions near the infrared range, and magnetic hyperthermia. CNT-QD-Fe3O4 developed exhibited a strong fluorescence near the infrared region for noninvasive optical in vivo imaging. Magnetization measurements showed nearly reversible hysteresis curves from CNT-QD-Fe3O4 nanoassembly. Fe3O4 conjugated CNT was found to experience hyperthermia heating under alternating electromagnetic field.


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