TITLE

Meta-Analysis of Antidepressant Augmentation: Piling on in the Absence of Evidence

AUTHOR(S)
Yury, Craig A.; Fisher, Jane E.; Antonuccio, David O.; Valenstein, Marcia; Matuszak, Jeremy
PUB. DATE
November 2009
SOURCE
Ethical Human Psychology & Psychiatry;2009, Vol. 11 Issue 3, p171
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Treatment of depression with a single pharmaceutical agent often does not work, and several agents may be tried or combined to increase efficiency. Augmentation involves the addition of one or more medications to an existing antidepressant monotherapy to enhance mood and overall antidepressant response. Approximately 22% of individuals with unipolar depression are prescribed augmentation strategies. This study examined the effectiveness of augmentation strategies. Methods: A Medline search of studies published before January 1, 2007 was conducted to assess the extent of published data on the most frequently prescribed augmentation strategies. Studies with completed original data, sufficient efficacy data, and participants diagnosed with unipolar depression were included. Letters to the editor, preliminary data, data only presented at conferences, and small uncontrolled case reports were excluded. Results: 13 studies contained sufficient data to calculate an effect size. Mean estimated effect size of all 13 studies calculated with random effects was 0.1782 with a 95% confidence interval of -0.2513-0.6076. Conclusions: There are minimal published data examining antidepressant augmentation, and augmentation is a minimally effective treatment option.
ACCESSION #
45587384

 

Related Articles

  • Phenelzine and Amitriptyline: Effects on Symptoms of Neurotic Depression. Rowan, P. A.; Paykel, E. S.; Parker, R. R. // British Journal of Psychiatry;May82, Vol. 140, p475 

    A double-blind controlled trial of phenelzine, amitriptyline and placebo was carried out in out-patients suffering from depression or mixed anxiety and depression. After six weeks treatment both active drugs were clearly superior to placebo and of similar efficacy; therapeutic effects started to...

  • Efficacy and Tolerability of Milnacipran in the Treatment of Major Depression in Comparison with Other Antidepressants: A Systematic Review and Meta-Analysis. Nakagawa, Atsuo; Watanabe, Norio; Omori, Ichiro M; Barbui, Corrado; Cipriani, Andrea; McGuire, Hugh; Churchill, Rachel; Furukawa, Toshi A // CNS Drugs;2008, Vol. 22 Issue 7, p587 

    BACKGROUND: Milnacipran, a dual serotonin-noradrenaline reuptake inhibitor, is one of the newer antidepressants that clinicians use for the routine care of patients with major depression. We undertook a systematic review and meta-analysis of randomized controlled trials that compared the...

  • JAMA analysis stirs debate. M. I. // Medical Marketing & Media;Feb2010, Vol. 45 Issue 2, p18 

    The article reports on the meta-analysis which found that antidepressants are useful for patients with severe symptoms of depression but do not work any better than placebo in mild cases.

  • Escitalopram proves dominant over sertraline in MDD.  // PharmacoEconomics & Outcomes News;4/7/2007, Issue 525, p1 

    The article discusses research being done on the effectiveness of escitalopram in treating patients with major depressive disorder (MDD). It references a study by E. P. Armstrong and colleagues, published in the February 2007 issue of "Current Medical Research and Opinion." The study compared...

  • From the editors.  // Nature Reviews Neuroscience;Feb2006, Vol. 7 Issue 2, p85 

    Deals with the efficacy of antidepressants. Prevalence of depression; History of the development of the first antidepressant drug Iproniazid; Side effects of antidepressants.

  • Melancholy Nation. Schrof, Joannie M.; Schultz, Stacey // U.S. News & World Report;03/08/99, Vol. 126 Issue 9, p56 

    Discusses medical treatments for psychological depression. Debate over the merits of Prozac and other antidepressants; Question of whether too many people are taking such drugs and for the wrong reasons; Prevalence of depression in the United States; Antidepressants not effective for everyone;...

  • Meta-analysis of trials corn paring antidepressants with active placebos. Moncrieff, Joanna; Wessely, Simon; Hardy, Rebecca // British Journal of Psychiatry;Mar98, Vol. 172, p227 

    Background Unblinding effects may introduce bias into clinical trials. The use of active placebos to mimic side-effects of medication may therefore produce more rigorous evidence on the efficacy of antidepressants. Method Trials comparing antidepressants with active placebos were located. A...

  • Antidepressants increase child suicidal thoughts.  // GP: General Practitioner;3/10/2006, p13 

    The article focuses on a clinical study conducted in the U.S., according to which up to 3 per cent of children taking antidepressants might have increased suicidal thoughts or behaviour due to their medication. A meta-analysis of 24 trials of nine widely used antidepressants in more than 4,500...

  • Efficacy of escitalopram in the treatment of major depressive disorder compared with conventional selective serotonin reuptake inhibitors and venlafaxine XR: a meta-analysis. Kennedy, Sidney H.; Andersen, Henning F.; Lam, Raymond W. // Journal of Psychiatry & Neuroscience;Mar2006, Vol. 31 Issue 2, p122 

    Objective: Escitalopram is the most selective of the selective serotonin reuptake inhibitor (SSRI) antidepressants. Previous studies have suggested that escitalopram is superior to citalopram in efficacy. We conducted a meta-analysis of studies in which escitalopram was compared with other...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics