TITLE

Response to Vicriviroc in Treatment- Experienced Subjects, as Determined by an Enhanced-Sensitivity Coreceptor Tropism Assay: Reanalysis of AIDS Clinical Trials Group A5211

AUTHOR(S)
Zhaohui Su; Gulick, Roy M.; Krambrink, Amy; Coakley, Eoin; Hughes, Michael D.; Dong Han; Flexner, Charles; Wilkin, Timothy J.; Skolnik, Paul R.; Greaves, Wayne L.; Kuritzkes, Daniel R.; Reeves, Jacqueline D.
PUB. DATE
December 2009
SOURCE
Journal of Infectious Diseases;12/1/2009, Vol. 200 Issue 11, p1724
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The enhanced-sensitivity Trofile assay (Monogram Biosciences) was used to retest coreceptor use at both study screening and study entry for 118 treatment-experienced subjects in AIDS Clinical Trials Group A5211 who had CCR5-tropic (R5) virus detected by the original Trofile assay at study screening. Among 90 recipients of vicriviroc, a significantly (P < .001) greater mean reduction in HIV-1 RNA was observed in 72 subjects with R5 virus versus 15 subjects reclassified as having dual/mixed-tropic viruses at screening: -1.11 versus -0.09 log10 copies/mL at day 14 and -1.91 versus -0.57 log10 copies/mL at week 24, respectively. Results suggest that the enhanced-sensitivity assay is a better screening tool for determining patient eligibility for CCR5 antagonist therapy.
ACCESSION #
45566197

 

Related Articles

  • Help wanted.  // Canadian Family Physician;Feb2008, Vol. 54 Issue 2, p248 

    The article announces that HIV-positive patients are needed to take part in HIV clinical trials to assess whether the advantages of a particular treatment or procedure outweigh its risk and if it will prevent the spread of HIV or improve the quality of life. Relative to this, the Canadian HIV...

  • BBC apologizes for airing AIDS 'denialist' documentary. Hughes, Virginia // Nature Medicine;Dec2007, Vol. 13 Issue 12, p1391 

    The article reports on the apology given by the British Broadcasting Corp. for airing a documentary that claimed HIV-positive orphans were exploited in clinical trials of AIDS drugs. The apology is an answer to complaints by several prominent AIDS scientists that the video, "Guinea Pig Kids,"...

  • Attitudes and Perceptions of AIDS Clinical Trials Group Site Coordinators on HIV Clinical Trial Recruitment and Retention: A Descriptive Study. King, William D.; Defreitas, Donna; Smith, Kimberly; Andersen, Janet; Perry, Lisa Patton; Adeyemi, Toyin; Mitty, Jennifer; Fritsche, Jan; Jeffries, Carrie; Littles, Melvin; Fischl, Margaret; Pavlov, Gregory; Mildvan, Donna // AIDS Patient Care & STDs;Aug2007, Vol. 21 Issue 8, p551 

    HIV-seropositive blacks, Hispanics, women of all ethnicities, and injection drug users (IDUs) have low rates of clinical trial participation. The opinions of research nurses and study coordinators as potential facilitators and barriers to access to clinical trials may contribute to this...

  • Personalized Medicine Development. Newman, Thomas J.; Freitag, Jeffrey J. // Applied Clinical Trials;Jul2011, Vol. 20 Issue 7, p30 

    The article discusses the role of the clinical research organization (CRO) that continues to develop as the popularity of personalized medicine grows in the U.S. It offers an overview of the services offered by CROs in assisting sponsors of personalized clinical trials. Also, it provides...

  • Monitoring and Ensuring Safety During Clinical Research. Morse, Michael A.; Califf, Robert M.; Sugarman, Jeremy // JAMA: Journal of the American Medical Association;3/7/2001, Vol. 285 Issue 9, p1201 

    Addresses concerns regarding the protection of human subjects in clinical trials. Description of the manner in which adverse event reporting might function to enhance safety; Role of data monitoring committees in using aggregate data from these reports; Problems that exist for institutional...

  • CONSORT statement: extension to cluster randomised trials. Campbell, Marion K.; Elbourne, Diana R.; Altman, Douglas G. // BMJ: British Medical Journal (International Edition);3/20/2004, Vol. 328 Issue 7441, p702 

    Offers a look at the effective reporting of randomized controlled trials. Guidelines in the Consolidated Standards of Reporting Trials (CONSORT) statement; Discussion of methodological issues in cluster randomized trials; Quality of reporting of cluster trials; Extension of CONSORT statement to...

  • Evidence supporting platform-switching to preserve marginal bone levels not definitive. Stafford, Gary L // Evidence-Based Dentistry;Jun2012, Vol. 13 Issue 2, p56 

    Data sourcesMEDLINE, EMBASE, The Cochrane Oral Health Group's Trials Register, The Cochrane Central Register of Controlled Trials (CENTRAL), UK National Research Register, Australian New Zealand Clinical Trials Registry (ANZCTR), Database of Abstracts of Reviews of Effectiveness (DARE), ISI...

  • Let's Bring the Trial to the Subject! Hynes, Tim // Applied Clinical Trials;Jul2005, Vol. 14 Issue 7, p58 

    Focuses on the compliance and retention issues in a clinical trial. Assessment of the typical response to recruitment and retention problems; Visitation of the subject in the comfort and privacy of the home; Continuation of in-home visits performed by a qualified homecare agency; Consideration...

  • Fully informed consent is impossible in surgical clinical trials. Bernstein, Mark // Canadian Journal of Surgery;Aug2005, Vol. 48 Issue 4, p271 

    This article reports that fully informed consent by patient is impossible in surgical clinical trials. Consent for an investigative procedure has 3 distinct but interrelated elements that are essentially the same as for purely therapeutic procedures: disclosure, capacity and voluntariness. It is...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics