TITLE

Dengue Virus Infections and Maternal Antibody Decay in a Prospective Birth Cohort Study of Vietnamese Infants

AUTHOR(S)
Tran Nguyen Bich Chau; Nguyen Trong Hieu; Anders, Katherine L.; Wolbers, Marcel; Le Bich Lien; Lu Thi Minh Hieu; Tran Tinh Hien; Nguyen Thanh Hung; Farrar, Jeremy; Whitehead, Stephen; Simmons, Cameron P.
PUB. DATE
December 2009
SOURCE
Journal of Infectious Diseases;12/15/2009, Vol. 200 Issue 12, p1893
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Dengue hemorrhagic fever can occur in primary dengue virus (DENV) infection of infants. The decay of maternally derived DENV immunoglobulin (Ig) G and the incidence of DENV infection were determined in a prospectively studied cohort of 1244 Vietnamese infants. Higher concentrations of total IgG and DENV-reactive IgG were found in cord plasma relative to maternal plasma. Maternally derived DENV-neutralizing and E protein-reactive IgG titers declined to below measurable levels in 190% of infants by 6 months of age. In contrast, IgG reactive with whole DENV virions persisted until 12 months of age in 20% of infants. Serological surveillance identified 10 infants with asymptomatic DENV infection for an incidence of 1.7 cases per 100 person-years. DENV-neutralizing antibodies remained measurable for ⩾1 year after infection. These results suggest that whereas DENV infection in infants is frequently subclinical, there is a window between 4 and 12 months of age where virion-binding but nonneutralizing IgG could facilitate antibody-dependent enhancement.
ACCESSION #
45545623

 

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