TITLE

Solid-Phase Synthesis of Optically Active Substituted 2-Aminofuranones Using an Activated Carbonate Linker

AUTHOR(S)
Matiadis, Dimitris; Prousis, Kyriakos C.; Igglessi-Markopoulou, Olga
PUB. DATE
October 2009
SOURCE
Molecules;Oct2009, Vol. 14 Issue 10, p3914
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
An efficient three-step solid-phase synthesis of diverse 3,5-disubstituted-2- aminofuranones has been developed. α-Hydroxy acids loaded on a nitrophenyl carbonate derivative of Wang resin are used as acylating agents for the C-acylation of active methylene compounds and the resulting intermediates provided, through a cyclative cleavage reaction, the desired product.
ACCESSION #
45446589

 

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