Antiretroviral Strategies to Prevent Mother-to-Child Transmission of HIV: Striking a Balance between Efficacy, Feasibility, and Resistance

Lehman, Dara A.; John-Stewart, Grace C.; Overbaugh, Julie
October 2009
PLoS Clinical Trials;Oct2009, Vol. 6 Issue 10, Special section p1
Academic Journal
The article discusses the use of antiretrovirals in preventing mother-to-child transmission (MTCT) of HIV. One study examined the effectiveness of adding up to a week of twice-daily zidovudine/lamivudine (AZT/3TC) to a single-dose of nevirapine (sdNVP) in reducing the risk of resistance in mothers and infants. The results of the study have led to a change in the World Health Organization's (WHO) recommendations for preventing MTCT in resource-limited settings.


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