Rosiglitazone was noninferior to metformin plus sulfonylurea for CV events but increased risk for HF and fractures in type 2 diabetes

Lipscombe, Lorraine L.; Home, P. D.
October 2009
ACP Journal Club;10/20/2009, Vol. 151 Issue 4, p5
Academic Journal
The article discusses a study on the relation between rosiglitazone (RGZ) and metformin (MFN) or sulfonylurea (SFU) for cardiovascular (CV) results in type 2 diabetics. The results indicate that RGZ added to MFN or SFU was not less effective as compared to MFN and SFU for overall cardiovascular safety but also showed greater risks for heart failure and fractures.


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