TITLE

Crosstalk between angiogenesis, cytokeratin-18, and insulin resistance in the progression of non-alcoholic steatohepatitis

AUTHOR(S)
Kitade, Mitsuteru; Yoshiji, Hitoshi; Noguchi, Ryuichi; Ikenaka, Yasuhide; Kaji, Kosuke; Shirai, Yusaku; Yamazaki, Masaharu; Uemura, Masahito; Yamao, Junichi; Fujimoto, Masao; Mitoro, Akira; Toyohara, Masahisa; Sawai, Masayoshi; Yoshida, Motoyuki; Morioka, Chie; Tsujimoto, Tatsuhiro; Kawaratani, Hideto; Fukui, Hiroshi
PUB. DATE
November 2009
SOURCE
World Journal of Gastroenterology;11/7/2009, Vol. 15 Issue 41, p5193
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
AIM: To elucidate the possible crosstalk between angiogenesis, cytokeratin-18 (CK-18), and insulin resistance (IR) especially in patients with non-alcoholic steatohepatitis (NASH). METHODS: Twenty-eight patients with NASH and 11 with simple fatty liver disease (FL) were enrolled in this study and underwent clinicopathological examination. The measures of angiogenesis, CK-18, and IR employed were CD34-immunopositive vessels, CK-18-immunopositive cells, and homeostasis model assessment of IR (HOMA-IR), respectively. The correlations of these factors with NASH were elucidated. RESULTS: Significant development of hepatic neovascularization was observed only in NASH, whereas almost no neovascularization could be observed in FL and healthy liver. The degree of angiogenesis was almost parallel to liver fibrosis development, and both parameters were positively correlated. Similarly, CK-18 expression and HOMA-R were significantly increased in NASH as compared with FL and healthy liver. Furthermore, CK-18 and HOMA-IR were also positively correlated with the degree of neovascularization. CONCLUSION: These results indicate that the crosstalk between angiogenesis, CK-18, and IR may play an important role in the onset and progression of NASH.
ACCESSION #
45308186

 

Related Articles

  • A case-control study on insulin resistance, metabolic co-variates & prediction score in non-alcoholic fatty liver disease. Bajaj, S.; Nigam, P.; Luthra, A.; Pandey, R. M.; Kondal, D.; Bhatt, S. P.; Wasir, J. S.; Misra, A. // Indian Journal of Medical Research;Mar2009, Vol. 129 Issue 3, p285 

    Background & objectives: Asian Indians have a high prevalence of insulin resistance and the metabolic syndrome. Currently, non-alcoholic fatty, liver disease (NAFLD) is considered to he an integral part of the metabolic syndrome with insulin resistance as a central pathogenic factor. We studied...

  • The blind men 'see' the elephant-the many faces of fatty liver disease. Sanal, Madhusudana Girija; Hübscher, Stefan G. // World Journal of Gastroenterology;2/14/2008, Vol. 14 Issue 6, p831 

    Nonalcoholic fatty liver disease (NAFLD) is a group of diseases with excess fat in liver in the absence of a poorly defined limit of alcohol consumption. Most common variety, a universal public health problem, is associated with insulin resistance caused by a host of genetic and epigenetic...

  • Circulating Level of CTRP1 in Patients with Nonalcoholic Fatty Liver Disease (NAFLD): Is It through Insulin Resistance? Shabani, Parisa; Naeimi Khaledi, H; Beigy, Maani; Emamgholipour, Solaleh; Parvaz, Eskandar; Poustchi, Hossein; Doosti, Mahmood // PLoS ONE;Mar2015, Vol. 10 Issue 3, p1 

    Nonalcoholic fatty liver disease (NAFLD) is considered as one of the most common liver diseases. It is robustly linked to obesity and insulin resistance and is regarded as hepatic manifestation of metabolic syndrome (MetS). Adipokines are involved in the pathophysiology of liver diseases. The...

  • Insulin Sensitivity and Lipid Metabolism in Human CD36 Deficiency. Furuhashi, Masato; Ura, Nobuyuki; Nakata, Tomoaki; Shimamoto, Kazuaki // Diabetes Care;Feb2003, Vol. 26 Issue 2, p471 

    OBJECTIVE — CD36 has been proposed as a fatty acid translocase and a receptor for HDL and oxidized LDL. The association between CD36 deficiency and insulin resistance remains controversial. We investigated glucose and lipid metabolism in human CD36 deficiency. RESEARCH DESIGN AND METHODS...

  • Non-alcoholic fatty liver disease in patients with migraine. Celikbilek, Asuman; Celikbilek, Mehmet; Okur, Aylin; Dogan, Serkan; Borekci, Elif; Kozan, Mustafa; Gursoy, Sebnem // Neurological Sciences;Oct2014, Vol. 35 Issue 10, p1573 

    Evidence suggests that migraine is associated with metabolic syndrome, which is also implicated in non-alcoholic fatty liver disease (NAFLD). Reported for the first time, we aimed to investigate the relationship between migraine and NAFLD in patients with migraine. A total of 90 consecutive...

  • Hybrid training of voluntary and electrical muscle contractions reduces steatosis, insulin resistance, and IL-6 levels in patients with NAFLD: a pilot study. Kawaguchi, Takumi; Shiba, Naoto; Maeda, Takashi; Matsugaki, Toru; Takano, Yoshio; Itou, Minoru; Sakata, Masahiro; Taniguchi, Eitaro; Nagata, Kensei; Sata, Michio // Journal of Gastroenterology;Jun2011, Vol. 46 Issue 6, p746 

    Background: Physical inactivity is a risk factor for the development of non-alcoholic fatty liver disease (NAFLD). 'Hybrid training', a training that involves both voluntary and electrical muscle contractions, causes beneficial alterations in muscles even after short durations of exercise. The...

  • CRYPTOGENIC CIRRHOSIS: METABOLIC LIVER DISEASE DUE TO INSULIN RESISTANCE. DE, BINAY K.; MANI, SIDDHARTHA; MANDAL, SANJAY K.; MONDAL, SOUMYA S.; BHATTACHARYA, RAJA; PRAMANIK, APURBA B.; SAU, DEBJOY; BHATTACHARJEE, KAUSHIK; JOARDAR, SWARNALI // Indian Journal of Medical Sciences;Nov2010, Vol. 64 Issue 11, p508 

    OBJECTIVE: Etiopathogenesis of cryptogenic cirrhosis (CC) is not yet well established. Up to 20% of non-alcoholic fatty liver disease (NAFLD) may progress to cirrhosis, mostly termed as cryptogenic. Insulin resistance and altered metabolic parameters form a major pathogenic link between NAFLD...

  • Venesection for non-alcoholic fatty liver disease unresponsive to lifestyle counselling—a propensity score-adjusted observational study. Valenti, L.; Moscatiello, S.; Vanni, E.; Fracanzani, A.L.; Bugianesi, E.; Fargion, S.; Marchesini, G. // QJM: An International Journal of Medicine;Feb2011, Vol. 104 Issue 2, p141 

    Background/Aim: To test the short-term clinical usefulness of venesection associated with lifestyle counselling as against counselling alone on insulin resistance and liver enzymes in subjects with non-alcoholic fatty liver disease (NAFLD), using a propensity score approach.Methods: We carried...

  • The role of ultrasonographic hepatic artery resistive index in the diagnosis of insulin resistance in obese children with non-alcoholic fatty liver disease. Hizli, Şamil; Koçyığıt, Ali; Arslan, Nur; Tuncel, Sedat; Demırcvoğlu, Fatih; Çakmakçi, Handan; Büyükgebız, Benal // Turkish Journal of Medical Sciences;Jun2010, Vol. 40 Issue 3, p335 

    Aim: To determine the role of hepatic artery resistive index (HARI) measurement in the prediction of insulin resistance (IR) in obese children with nonalcoholic fatty liver disease (NAFLD). Materials and methods: A total of 64 obese subjects with NAFLD (13.5 ± 1.36 years of age, 34 male) and...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics