Modification of sleep architecture in an animal model of experimental cirrhosis

Jiménez-Anguiano, Anabel; Díaz-Medina, Vanessa; Farfán-Labonne, Blanca Eugenia; Giono-Chiang, Gloria; Kersenobich, David; García-Lorenzana, Mario; Gutiérrez-Ruiz, Maria Concepción; Velázquez-Moctezuma, Javier
November 2009
World Journal of Gastroenterology;11/7/2009, Vol. 15 Issue 41, p5176
Academic Journal
AIM: To analyze the polygraphic sleep patterns during cirrhosis progression in a rat model by repeated CCl4 administration. METHODS: Male Wistar rats received three weekly injections of CCl4 for 11 wk, and were analyzed before and during the induction of cirrhosis. Rats were implanted with electrodes to record their sleep patterns. Polygraph recordings were made weekly over 11 wk for 8 h, during the light period. After a basal recording, rats received three weekly injections of CCl4. Histological confirmation of cirrhosis was performed after 11 wk. RESULTS: The results showed a progressive decrease in total wake time that reached statistical significance from the second week of treatment. In addition, there was an increase in total time of slow wave sleep (SWS) and rapid eye movement sleep (REM sleep) in most of the 11 wk. SWS I showed no significant variations. During the final weeks, a significant increase in REM sleep frequency was also observed. Histological analyses of the livers showed unequivocal signs of cirrhosis. CONCLUSION: These data suggest that hepatic failure produced by CCl4 administration is capable of modifying the sleep pattern even after only a few doses.


Related Articles

  • Effects of a single dose of 3,4-methylenedioxymethamphetamine on circadian patterns, motor activity and sleep in drug-naive rats and rats previously exposed to MDMA. Balogh, Brigitta; Molnar, Eszter; Jakus, Rita; Quate, Linda; Olverman, Henry J.; Kelly, Paul A. T.; Kantor, Sandor; Bagdy, Gyorgy // Psychopharmacology;2004, Vol. 173 Issue 3/4, p296 

    Rationale. Despite the well documented neurochemical actions of 3,4-methylenedioxymethamphetamine (MDMA), acute effects in rats previously exposed to the drug have not been extensively explored. Objective. To examine motor activity and vigilance effects of MDMA in drug-naive rats and in rats...

  • A deep and dreamy sleep.  // Prevention India;May2011, p4 

    The article discusses the significance and importance of sleeping. It is mentioned that there are two stages of sleep, the Rapid Eye Movement (REM) stage, and the Delta-wave, or slow-wave sleep and both act as general healer improving memory and decision making. Also, during sleep body secretes...

  • Sleep: The Pattern of Life. Pilcher, June J. // Phi Kappa Phi Forum;Winter2015, Vol. 95 Issue 4, p14 

    The article explores the basic pattern of human sleep and its specific stages. Topics covered include the electrical activity in the brain when a person is relaxed and is going to sleep, the eye movement during a slow wave sleep, the characteristics of rapid eye movement (REM) sleep, and the...

  • Correlations between adolescent processing speed and specific spindle frequencies. Nader, Rebecca S.; Smith, Carlyle T. // Frontiers in Human Neuroscience;Feb2015, Vol. 9, p1 

    Sleep spindles are waxing and waning thalamocortical oscillations with accepted frequencies of between 11 and 16 Hz and a minimum duration of 0.5 s. Our research has suggested that there is spindle activity in all of the sleep stages, and thus for the present analysis we examined the link...

  • Representation of Self in SWS and REM Dreams. Occhionero, Miranda; Cicogna, PierCarla; Natale, Vincenzo; Esposito, Maria José; Bosinelli, Marino // Sleep & Hypnosis;2005, Vol. 7 Issue 2, p77 

    The aim of this study was to compare the representation of self in REM and SWS Dreams. Ninety volunteers slept two non-consecutive nights in the sleep laboratory under electropolygraphic control. They were awakened for one report per night. Awakenings were made, in counterbalanced order, from...

  • No effect of odor-induced memory reactivation during REM sleep on declarative memory stability. Cordi, Maren J.; Diekelmann, Susanne; Born, Jan; Rasch, Björn // Frontiers in Systems Neuroscience;Sep2014, Vol. 8, p1 

    Memory reactivations in hippocampal brain areas are critically involved in memory consolidation processes during sleep. In particular, specific firing patterns of hippocampal place cells observed during learning are replayed during subsequent sleep and rest in rodents. In humans, experimentally...

  • Sleep and Pain. Jin-Seong Lee; Do-Un Jeong // Sleep Medicine & Psychophysiology;2012, Vol. 19 Issue 2, p63 

    The reciprocal interaction between sleep and pain has been reported by numerous studies. Patients with acute or chronic pain often complain of difficulty falling asleep, frequent awakenings, shorter sleep duration, unrefreshing sleep, and poor sleep quality in general. According to the majority...

  • Gender and age influence the effects of slow-wave sleep on respiration in patients with obstructive sleep apnea. Subramanian, Shyam; Hesselbacher, Sean; Mattewal, Amarbir; Surani, Salim // Sleep & Breathing;Mar2013, Vol. 17 Issue 1, p51 

    Introduction: Obstructive sleep apnea (OSA) is influenced by sleep architecture with rapid eye movement (REM) sleep having the most adverse influence, especially in women. There is little data defining the influence of slow-wave sleep (SWS) on OSA. We wished to study the influence of SWS on OSA...

  • Differential Associations of Early- and Late-Night Sleep with Functional Brain States Promoting Insight to Abstract Task Regularity. Yordanova, Juliana; Kolev, Vasil; Wagner, Ullrich; Verleger, Rolf // PLoS ONE;2010, Vol. 5 Issue 2, p1 

    Background: Solving a task with insight has been associated with occipital and right-hemisphere activations. The present study tested the hypothesis if sleep-related alterations in functional activation states modulate the probability of insight into a hidden abstract regularity of a task....


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics