TITLE

Derivative Spectrophotometric Method for Simultaneous Estimation of nicotine and Bupropion Hydrochloride in Synthetic Mixture by Derivative Spectrophotometric Method

AUTHOR(S)
Patel, K. N.; Patel, J. K.; Rathod, I. S.
PUB. DATE
September 2009
SOURCE
Journal of Pharmacy Research;Sep2009, Vol. 2 Issue 9, p1525
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The use of first order derivative spectroscophotometry allowed simultaneous determination of nicotine and bupropion hydrochloride in fixed dose combination products. The absorbance values at 251.2 nm and 259.8 nm of first derivative spectrum was used for the estimation of nicotine and bupropion hydrochloride, respectively without mutual interference. This method obeyed Beer's law in the concentration range of 10-30 μg/ml for both nicotine and bupropion hydrochloride. The results of analysis have been validated statistically and recovery studies confirmed the accuracy of the proposed method.
ACCESSION #
45306564

 

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