TITLE

Treatment of sepsis in cardiac surgery: role of immunoglobulins

AUTHOR(S)
Sablotzki, A.; Mühling, J.; Dehne, M.; Zickmann, B.; Silber, R.; Friedrich, I.
PUB. DATE
March 2001
SOURCE
Perfusion;Mar2001, Vol. 16 Issue 2, p113
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Cardiopulmonary bypass (CPB) is associated with an injury that may cause pathophysiological changes such as systemic inflammatory response syndrome, multiple organ dysfunction syndrome, and mediator-induced multiorgan failure. Systemic endotoxinaemia, release of proinflammatory cytokines, and interactions between neutrophils and endothelium have been reported to correlate with a high incidence of organ dysfunction, infection and sepsis following cardiac surgery. This review discusses the dysregulation of the immune response as a major reason for the higher susceptibility to infections following cardiac surgery, various treatment strategies to reduce CPB-induced inflammation, and especially the prophylactic use of immunoglobulins in cardiac surgery.
ACCESSION #
4524367

 

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