TITLE

Evaluation of a new point of care heparin test for cardiopulmonary bypass: the TAS heparin management test

AUTHOR(S)
Wallock, M.; Jeske, W.P.; Bakhos, M.; Walenga, J.M.
PUB. DATE
March 2001
SOURCE
Perfusion;Mar2001, Vol. 16 Issue 2, p147
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Patients undergoing cardiopulmonary bypass (CPB) require anticoagulation with heparin to avoid thrombosis within the bypass circuit. The common method used to monitor the degree of anticoagulation is the activated clotting time (ACT). We evaluated a novel point of care device, the TAS (Pharmanetics, Raleigh, NC, USA) heparin management test (HMT), for its suitability in monitoring anticoagulation during CPB. In vitro analysis showed a dose-response (r[sup 2]=0.988) of the HMT from 0.078-10.0 U/ml heparin, covering the range of heparin used during cardiac surgery (2-5 U/ml). Fifty randomly selected patients undergoing CPB were studied. Preheparin clotting times for these patients were 143±32 s for the HMT and 146±18 s for the ACT; 435±60 s HMT and 438±39 s ACT during CPB; 145±50 s HMT and 128±14 s ACT post-protamine (r[sup 2]=0.797). Episilon-aminocaproic acid treatment for inhibition of fibrinolysis did not affect the HMT. We conclude that the HMT correlates well with the ACT and may be useful for monitoring heparin during CPB. Advantages of the HMT are small sample volume and good sensitivity to heparin.
ACCESSION #
4524363

 

Related Articles

  • Activated Coagulation Method in the Continuous Monitoring of Heparin Levels. Johnson, John L.; Ravi, Judson M.; Kafrouni, George; Lui, Alfred H. F. // Vascular Surgery;Sep/Oct1978, Vol. 12 Issue 5, p315 

    Describes the activated coagulation time (ACT) test process in the continuous monitoring of heparin levels during an acute procedure. Importance of heparin in clinical medicine; Establishment of normal values for the ACT test; Use of ACT during cardiopulmonary bypass surgery.

  • Editorial. Rubens, Fraser D. // Perfusion;May2011, Vol. 26 Issue 3, p173 

    The author strongly recommends the perfusion community to embrace new technologies, in particular the use of thromboelastography (TEG) in direct transfusion practice, to address the ever-changing environment of cardiovascular intervention. He references two articles in the same issue pertaining...

  • Heparins: Clinical Use and Laboratory Monitoring. Hoffman, Maureane // Laboratory Medicine;Oct2010, Vol. 41 Issue 10, p621 

    Heparin has long been used as an anti-thrombotic to treat and prevent thromboembolic events, as well as for systemic anti-coagulation during cardiopulmonary bypass and dialysis. Heparin continues to have distinct advantages when intense anti-coagulation is needed, but newer low molecular weight...

  • Phosphorylcholine coating offers natural platelet preservation during cardiopulmonary bypass. De Somer, F; Van Belleghem, Y; Caes, F; François, K; Arnout, J; Bossuyt, X; Taeymans, Y; Van Nooten, G // Perfusion;Jan2002, Vol. 17 Issue 1, p39 

    Return of blood activated by tissue factor is the main culprit for triggering the coagulation cascade. When this activated blood is diverted from the cardiopulmonary bypass (CPB) circuit, it becomes possible to evaluate the effect of surface treatment on platelet and complement activation....

  • Coagulation disorders of cardiopulmonary bypass: a review. Paparella, Domenico; Brister, Stephanie J.; Buchanan, Michael R. // Intensive Care Medicine;Oct2004, Vol. 30 Issue 10, p1873 

    Background: Postoperative bleeding is one of the most common complications of cardiac surgery.Discussion: Extensive surgical trauma, prolonged blood contact with the artificial surface of the cardiopulmonary bypass (CPB) circuit, high doses of heparin, and hypothermia...

  • Aortic valve replacement in a young patient with essential thrombocytosis. Ahmed, Kashif; Vohra, Hunaid A.; Milne, Alison; Langley, Stephen M. // Journal of Cardiothoracic Surgery;2008, Vol. 3, Special section p1 

    Essential Thrombocythcythaemia (ET) is an uncommon type of myeloproliferative disorder, characterised by both thrombotic and haemorrhagic diathesis. No clear guidelines exist for the pre-and post-operative management of patients undergoing cardiac surgery in the haematological and surgical...

  • Factores relacionados con hemorragia mayor durante la cirugía cardíaca bajo circulación extracorpórea. Hernández-González, Martha A.; Solorio, Sergio; Luna-Quintero, Carlos; Araiza-Guerra, Aurelio; Cruz-Cervantes, Raúl; Luna-Ramírez, Sergio; Murillo-Ortiz, Blanca; Cruz-Márquez-Rico, Luis Mariano // Archivos de Cardiología de México;jul-sep2008, Vol. 78 Issue 3, p273 

    Objective: To evaluate the risk factors related to bleeding in patients subjected to cardiac surgery using an extracorporeal circulation pump. Material and methods: A study of cases and controls was designed performed in adults, matched by age and gender with indication of elective cardiac...

  • Thrombocytopenia Associated with Antithrombotic Therapy in Patients with Cardiovascular Diseases: Diagnosis and Treatment. Kilickiran Avci, Burcak; Oto, Ali; Ozcebe, Osman // American Journal of Cardiovascular Drugs;2008, Vol. 8 Issue 5, p327 

    Agents with antiplatelet and anticoagulant activity have been proved to be effective in reducing the incidence of complications following acute coronary syndrome, percutaneous coronary intervention, and cardiopulmonary bypass. However, these agents, including heparin, glycoprotein IIb/IIIa...

  • Abrupt formation of intracardiac thrombus during cardiopulmonary bypass with full heparinization -A case report-. Seong-Hyop Kim; Jae-Sung Ryu; Tae-Yop Kim; Tae-Gyoon Yoon; Woonseok Kang; Ji Eun Song // Korean Journal of Anesthesiology;Feb2012, Vol. 62 Issue 2, p175 

    Intracardiac thrombus during cardiopulmonary bypass (CPB) with full heparinization is very rare but fatal. A 60-year-old woman was scheduled for aortic and mitral valve repairs with a maze procedure for mixed aortic and mitral valvular heart disease with atrial fibrillation. Preoperative...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics