September 2009
Problemy Terapii Monitorowanej;sep2009, Vol. 20 Issue 3, p159
Academic Journal
Ischaemia-modified albumin (IMA) obtained FDA registration as a marker of myocardial ischaemia. The aim of the study was to assess serum IMA levels during exercise test in patients with angina pectoris confirmed by coronarography. Material and methods: The study included 32 patients (27 men, 5 women), aged 31-71 years (mean 55.0 ±l; 10.6 years) with CCS class II stenocardial pain, with NYHA stage II heart failure and with left ventricular ejection fraction 62.4 ± 6.8%. Exercise test acc. to the Bruce protocol was performed in all the examined patients. After the test, the patients were divided into 2 groups: Group I - with positive exercise test (cardiac chest pain/or ST segment depression of at least 1 mm; median in the investigated group 1.8 ± 0.7 mm) and Group II -- with negative exercise test. The time of exercise in Group I was: 5.6 ± 2.3 min; in Group II -- 7.37 ± 2.4 min (p>0.05). Heart rate/min, systolic and diastolic arterial blood pressure, serum IMA level before exercise, directly afterwards and after 10-min rest did not differ significantly between the investigated groups. In Group I, serum IMA level before exercise was elevated in 95.0%, whereas in Group II in 91.7% (cut point 85 U/ml), while after the exercise and after 10-min rest it was elevated in 55.0% of Group I patients and in 41.7% of Group II patients. Troponin T level before exercise, directly afterwards and after 10-min. rest was <0.01 ng/ml. Coronarography demonstrated vasoconstriction > 70% in main coronary vessels in17(85.0%) patients of Group I. Coronarography was not performed in Group II. Conclusion: The determination of ischaemia-modified albumin does not improve the diagnostic value of exercise test in patients with coronary vessels disease.


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