TITLE

Regenerative Therapy in Peripheral Artery Disease

AUTHOR(S)
Germani, Antonia; Di Campli, Cristiana; Pompilio, Giulio; Biglioli, Paolo; Capogrossi, Maurizio C.
PUB. DATE
December 2009
SOURCE
Cardiovascular Therapeutics;Dec2009, Vol. 27 Issue 4, p289
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Patients with peripheral artery disease (PAD) and critical limb ischemia are the main candidates for limb amputations and have a poor life expectancy. Frequently, these patients are not eligible for either surgical or percutaneous interventions aimed at mechanical revascularization. Therefore, new strategies need to be identified to offer these patients a viable therapeutic option. Gene and cell therapy hold great promise for the treatment of peripheral vascular diseases because, in animal models, local delivery of growth factors and endothelial progenitor cells result in new blood vessel formation and regeneration of ischemic tissues. In this article, are reviewed phase I and phase II gene, and cell therapy clinical trials in patients with PAD.
ACCESSION #
45064380

 

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