TITLE

A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos

AUTHOR(S)
Iwata, Tomoko
PUB. DATE
July 2000
SOURCE
Human Molecular Genetics;Jul2000, Vol. 9 Issue 11, p1603
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Studies the effect of mutation in FGFR3 on growth plate chondrocytes in embryos. Generation of the first mouse model of fibroblast growth factor receptor 3 with the K644E mutation; Embryonic onset of a neonatal lethal dwafism.
ACCESSION #
4504409

 

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