Efficacy and safety of rabeprazole in non-steroidal anti-inflammatory drug-induced ulcer in Japan

Mizokami, Yuji; Slomiany, Bronislaw L.
October 2009
World Journal of Gastroenterology;10/28/2009, Vol. 15 Issue 40, p5097
Academic Journal
AIM: To investigate the efficacy and safety of rabeprazole under continuous non-steroidal anti-inflammatory drug (NSAID) administration for NSAID-induced ulcer in Japan. METHODS: Subjects comprised patients undergoing NSAID treatment in whom upper gastrointestinal endoscopy revealed an ulcerous lesion (open ulcer) with diameter ≥ 3 mm, who required continuous NSAID treatment. Endoscopies were performed at the start of treatment, during the treatment period, and at the conclusion (or discontinuation) of treatment. Findings were evaluated as size (maximum diameter) and stage based on the Sakita-Miwa classification. An ulcer was regarded as cured when the "white coating" was seen to have disappeared under endoscopy. As criteria for evaluating safety, all medically untoward symptoms and signs (adverse events, laboratory abnormalities, accidental symptoms, etc.) occurring after the start of rabeprazole treatment were handled as adverse events. RESULTS: Endoscopic cure rate in 38 patients in the efficacy analysis (endoscopic evaluation) was 71.1% (27/38). Among those 38 patients, 35 had gastric ulcer with a cure rate of 71.4% (25/35), and 3 had duodenal ulcer with a cure rate of 66.7% (2/3). Three adverse drug reactions were reported from 64 patients in the safety analysis (interstitial pneumonia, low white blood cell count and pruritus); thus, the incidence rate for adverse drug reactions was 4.7% (3/64). CONCLUSION: The treatment efficacy of rabeprazole for NSAID-induced ulcer under continuous NSAID administration was confirmed.


Related Articles

  • The over-the-counter ulcer. Dickinson, Ben // Esquire;Oct97, Vol. 128 Issue 4, p137 

    Reports that over-the-counter self-medicating can cause ulcer. Nonsteroidal anti-inflammatory drug (NSAID) effects; Types of NSAID drugs; Guidelines on how to minimize the NSAID effects.

  • High-dose famotidine is an effective therapy for NSAID-associated ulcers.  // Modern Medicine;Sep97, Vol. 65 Issue 9, p56 

    Presents an abstract of the article `Famotidine for Healing and Maintenance in Nonsteroidal Anti-inflammatory Drug-Associated Gastroduodenal Ulceration,' by N. Hudson, A.S. Taha et al published in the June 1997 issue of `Gastroenterology' journal.

  • Bioregulatory Management of Peptic Ulcer Disease. Lescheid, David W. // International Journal of Aquatic Research & Education;May2015, Vol. 9 Issue 2, Special section p24 

    The article discusses the bioregulatory treatment of peptic ulcer disease (PUD), a gastrointestinal system disease common in industrialized nations. Topics include prevalence of PUD in the U.S., epigastric pain as the most common symptom of PUD, and use of nonsteroidal anti-inflammatory drugs...

  • New treatment guidelines target NSAID-induced ulcers. Portyansky, Elena // Drug Topics;11/2/98, Vol. 142 Issue 21, p24 

    Discusses the guidelines for the management of ulcers caused by nonsteroidal anti-inflammatory drugs (NSAID), published in the November 1998 issue of the `American Journal of Gastroenterology.' Use of misoprostol as a preventive strategy; Warning against the erroneous practice of using H2...

  • Gastrointestinal Side Effects of Rofecoxib and Naproxen. Lisse, J.R.; Perlman, M.; Johansson, G.; Shoemaker, J.R.; Schechtman, J.; Skalky, C.S.; Dixon, M.E.; Polis, A.B.; Mollen, A.J.; Geba, G.P. // Annals of Internal Medicine;10/7/2003, Vol. 139 Issue 7, pI29 

    Osteoarthritis is a joint disease that gradually wears down cartilage and bone. It is the most common joint disorder worldwide, affecting both men and women as they grow older. Symptoms include pain and stiffness of the fingers and weight-bearing joints, such as the knees, back, and hips....

  • Arthritis help. Tannis, Allison // Alive: Canada's Natural Health & Wellness Magazine;Feb2005, Issue 268, p74 

    Focuses on the consideration of the osteoarthritis as most debilitating type of arthritis. Result of wear and tear on joint cartilage; Side effects and effectiveness of the non-steroidal anti-inflammatory drugs; Supplementation of S-adenosylmethionine to reduce the pain of ostheoarthritis.

  • Gastroprotective analgesia. Farrer, F. // South African Pharmacist's Assistant;Winter2011, Vol. 11 Issue 2, p28 

    The article reports on the effectiveness of nonsteroidal antiinflammatory drugs (NSAIDs) as analgesic, antipyretic and anti-inflammatory agents. It states that NSAIDs act by inhibiting the enzyme, cyclo-oxygenase (COX), is responsible for the synthesis of prostaglandins (PGs), resulting to pain...

  • Comparison of drug therapies for NSAID-induced ulcers.  // Modern Medicine;Jun98, Vol. 66 Issue 6, p15 

    Presents the abstracts of the articles `A Comparison of Omeprazole With Ranitidine for Ulcers Associated With Nonsteroidal Antiinflammatory Drugs,' from the `New England Journal of Medicine,' dated March 12, 1998 and `Omeprazole Compared with Misoprostol for Ulcers Associated With Nonsteroidal...

  • Safety of Oral Paracetamol - Analysis of Data from a Spontaneous Reporting System in Poland. Han, Stanisław; Kuchar, Ernest; Karłowicz-Bodalska, Katarzyna; Kutycka, Elżbieta; Miśkiewicz, Katarzyna; Nitsch-Osuch, Aneta // Tropical Journal of Pharmaceutical Research;Apr2014, Vol. 13 Issue 4, p617 

    Purpose: To determine the safety of oral coated paracetamol tablets 500 mg and oral suspension 120 mg/5 mL produced by Hasco-Lek Poland. Methods: We analyzed sales volume and data obtained from the monitoring of spontaneous reports on the adverse effects of paracetamol collected in the period...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics