Hepatitis C virus genotype 3a infection and hepatocellular carcinoma: Pakistan experience

Idrees, Muhammad; Rafique, Shazia; Rehman, Irshad-ur; Akbar, Haji; Yousaf, Muhammad Zubair; Butt, Sadia; Awan, Zunaira; Manzoor, Sobia; Akram, Madiha; Aftab, Mahwish; Khubaib, Bushra; Riazuddin, Sheikh; Sato, Chifumi; Chan, Henry L. Y.
October 2009
World Journal of Gastroenterology;10/28/2009, Vol. 15 Issue 40, p5080
Academic Journal
AIM: To assess the association between chronic hepatitis C virus (HCV) infection and hepatocellular carcinoma (HCC) in Pakistan, and the genotype distribution among these HCC patients. METHODS: One hundred and sixty-one subjects with HCC were included in this study. Liver biopsy was performed on 145 of the patients; sixteen were excluded because they failed to fulfill the inclusion criteria. Qualitative polymerase chain reaction (PCR) was performed for hepatitis B virus and HCV. Samples positive for HCV RNA were genotyped using genotype-specific PCR and confirmed by HCV 5' noncoding region sequencing analysis. RESULTS: Chronic HCV infection was identified a major risk factor (63.44% of tested HCC patients) for the development of HCC. The time from HCV infection to appearance of cancer was 10-50 years. In the HCC patient population, broader distributions of genotypes were present with genotype 3a as the predominant genotype. Using the type-specific genotyping method, we found HCV genotype 3a in 40.96%, 3b in 15.66%, 1a in 9.63%, and 1b in 2.40% of HCC tissue samples. About 28% of cases were found with mixed genotypes. Two cases were unable to be genotyped because of low viral load. Sixty-six percent of treated patients with cirrhosis had an end of treatment response, but unfortunately they relapsed quickly when the treatment was discontinued, and HCC developed during a median 3.8 years. CONCLUSION: There was a strong association between chronic HCV infection and HCC in Pakistan, and between HCV genotype 3a and HCC.


Related Articles

  • Regular surveillance by imaging for early detection and better prognosis of hepatocellular carcinoma in patients infected with hepatitis C virus. Noda, Ikue; Kitamoto, Mikiya; Nakahara, Hideki; Hayashi, Ryohei; Okimoto, Tomoaki; Monzen, Yoshio; Yamada, Hiroyasu; Imagawa, Masaru; Hiraga, Nobuhiko; Tanaka, Junko; Chayama, Kazuaki // Journal of Gastroenterology;Jan2010, Vol. 45 Issue 1, p105 

    This study evaluated the usefulness of regular check-ups by ultrasonography and contrast-enhanced imaging for early detection of hepatocellular carcinoma (HCC) in a retrospective analysis. From April 2001 to March 2007, 240 consecutive patients with HCC who were infected with hepatitis C virus...

  • HCV protein causes cancer.  // AIDS Patient Care & STDs;Dec98, Vol. 12 Issue 12, p943 

    Discusses findings of Japanese researchers that the hepatitis C virus (HVC) core protein induces hepatocellular carcinoma. Development of hepatic steatosis in laboratory mice as histologic feature of chronic hepatitis C; Characteristics of mice carrying HCV envelope genes.

  • Incomplete response of interferon treatment has an important role for the prevention of hepatocellular carcinoma. Hayashi, Norio // Journal of Gastroenterology;1999, Vol. 34 Issue 5, p655 

    Editorial. Focuses on the incidence of hepatocellular carcinoma (HCC) in Japan. Incidence rate of HCC in cirrhotic patients with antibodies to hepatitis C virus (HCV); Treatment of HCV.

  • Iron, hepatitis C virus, and hepatocellular carcinoma: iron reduction preaches the gospel for chronic hepatitis C. Fujita, Naoki; Takei, Yoshiyuki // Journal of Gastroenterology;Nov2007, Vol. 42 Issue 11, p923 

    The article discusses various reports publishes within the issue, including one on chronic hepatitis C virus and another on iron reduction.

  • Hepatocellular carcinoma: advances in proteomics. Chattopadhyay, Dipankar; Reeves, Helen L. // Hot Topics in Viral Hepatitis;2011, Vol. 7 Issue 21, p23 

    The incidence of hepatocellular carcinoma (HCC) is rising dramatically in Europe, driven by the increasing prevalence of cirrhosis associated with hepatitis C virus (HCV) infection and both alcoholic and nonalcoholic fatty liver diseases (ALD and NAFLD, respectively). At the 2011 "Women in...

  • Distribution of Hepatitis C virus genotypes in city of Mashhad, North-east of Iran. Rastin, M.; Mahmoudi, M.; Rezaee, S. A.; Assarehzadegan, M. A.; Tabasi, N.; Zamani, S.; Nosratabadi, R.; Haghmorad, D.; Sheikh, A.; Khazaee, M.; Panah, H. R. // Indian Journal of Medical Microbiology;Jan2014, Vol. 32 Issue 1, p53 

    Purpose: Six major hepatitis C virus genotypes have been characterised, which vary in their geographical distribution. The prevalence of hepatitis C virus (HCV) in an area is not constant, and depends on the changes in route of infection, which may change over time. In this study, the...

  • Interferon Therapy after Tumor Ablation Improves Prognosis in Patients with Hepatocellular Carcinoma Associated with Hepatitis C Virus. Shiratori, Yasushi; Shiina, Shuichiro; Teratani, Takuma; Imamura, Masatoshi; Obi, Shun'taro; Sato, Shin'pei; Koike, Yukihiro; Yoshida, Haruhiko; Omata, Masao // Annals of Internal Medicine;2/18/2003, Vol. 138 Issue 4, p299 

    Studies the efficacy of interferon therapy in patients with hepatocellular carcinoma associated with hepatitis C virus. Criteria for interferon response; Factors associated with sustained response; Adverse events and tolerance; Development of foci of hepatocellular carcinoma; Survival rate of...

  • Abnormalities identified in the liver after HCV eradication. Pockros, Paul J. // Infectious Disease News;Dec2011, Vol. 24 Issue 12, p19 

    The article discusses research from Japan which revealed histological abnormalities in noncancerous liver tissues of patients with hepatocellular cancer following hepatitis C (HCV) eradication.

  • Development of hepatocellular carcinoma after longterm sustained complete response to interferon therapy: what is the mechanism? Tanaka, Naoki; Kiyosawa, Kendo // Journal of Gastroenterology;2003, Vol. 38 Issue 4, p417 

    Editorial. Points out that the development of hepatocellular carcinoma (HCC) after a sustained complete response to interferon presents an interesting and important problem. Development of HCC after a sustained complete response following completion of interferon therapy; Role of the hepatitis...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics