TITLE

High circulating N-terminal pro-brain natriuretic peptide and tumor necrosis factor-α in mixed cryoglobulinemia

AUTHOR(S)
Antonelli, Alessandro; Ferri, Clodoveo; Ferrari, Silvia Martina; Galetta, Fabio; Franzoni, Ferdinando; Santoro, Gino; De Marco, Salvatore; Ghiri, Emiliano; Fallahi, Poupak; Sansonno, Domenico
PUB. DATE
October 2009
SOURCE
World Journal of Gastroenterology;10/28/2009, Vol. 15 Issue 40, p5074
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
AIM: To evaluate serum levels of N-terminal pro-brain natriuretic peptide (NTproBNP) and tumor necrosis factor α (TNF-α) in a large series of patients with hepatitis C associated with mixed cryoglobulinemia (MC+HCV). METHODS: Serum NTproBNP and TNF-α levels were assayed in 50 patients with MC+HCV, and in 50 sex-and age-matched controls. RESULTS: Cryoglobulinemic patients showed significantly higher mean NTproBNP and TNF-a levels than controls ( P < 0.001; Mann-Whitney U test). By defining high NTproBNP level as a value higher than 125 pg/mL (the single cut-off point for outpatients under 75 years of age), 30% of MC+HCV and 6% of controls had high NTproBNP (?², P < 0.01). With a cut-off point of 300 pg/mL (used to rule out heart failure (HF) in patients under 75 years of age), 8% of MC+HCV and 0 controls had high NTproBNP (?², P < 0.04). With a cut-off point of 900 pg/mL (used for ruling in HF in patients aged 50-75 years; such as the patients of our study), 6% of MC+HCV and 0 controls had high NTproBNP (?², P = 0.08). CONCLUSION: The study demonstrates high levels of circulating NTproBNP and TNF-α in MC+HCV patients. The increase of NTproBNP may indicate the presence of a subclinical cardiac dysfunction.
ACCESSION #
44922491

 

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