TITLE

Liver tumor infiltrating lymphocytes: Comparison of hepatocellular and cholangiolar carcinoma

AUTHOR(S)
Kasper, Hans-Udo; Drebber, Uta; Stippel, Dirk Ludger; Dienes, Hans Peter; Gillessen, Anton; Gorrell, Mark D.
PUB. DATE
October 2009
SOURCE
World Journal of Gastroenterology;10/28/2009, Vol. 15 Issue 40, p5053
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
AIM: To investigate the role of tumor infiltrating lymphocytes (TIL) in primary hepatocellular and cholangiolar carcinomas of the liver. METHODS: Immunohistochemical analysis was performed including antibodies to CD3, CD4, CD8, CD20, CD56 and TIA-1 in formalin-fixed and paraffin-embedded tissue of 35 liver resection specimens of hepatocellular or cholangiocellular carcinomas. Semiquantitative evaluation was performed with emphasis on the area of the tumor itself and of the tumor/liver interface. RESULTS: All hepatocellular carcinomas showed infiltration of lymphocytes predominantly around the tumor in the tumor/liver interface consisting mainly of CD3+ CD4+ T lymphocytes [164.3/10 high power fields (HPF)] and in the tumor itself of CD8+ cells (54.9/10 HPF). Cholangiocarcinomas contained a heterogeneous amount of TIL, composed mainly of CD3+ T cells with a predominance of CD8+ cells in the tumor tissue (52.6/10 HPF) and of CD4+ cells in the interface region (223.1/10 HPF). CD56+ cells of the innate immune system were scarce. There was no significant difference between hepatocellular or cholangiolar carcinoma. No correlation with the clinicopathological data was seen. CONCLUSION: Liver TIL consists of intratumoral CD8+ T cells and peritumoral CD4+ T cells independent of histogenetic origin. Different functions of lymphocytes in these regions seem possible.
ACCESSION #
44922488

 

Related Articles

  • Vitronectin in human hepatic tumours contributes to the recruitment of lymphocytes in an alpha v beta3-independent manner. Edwards, S.; Lalor, P. F.; Tuncer, C.; Adams, D. H. // British Journal of Cancer;12/4/2006, Vol. 95 Issue 11, p1545 

    The degree of lymphocyte infiltration is a prognostic factor in liver cancer, but to date the mechanisms by which lymphocytes infiltrate into and are retained in hepatic tumours are poorly understood. We hypothesised that the extracellular matrix glycoprotein vitronectin, a major component of...

  • Liver Cancer, molecular biology. Buendia, Marie Annick // Encyclopedic Reference of Cancer;2001, p503 

    A definition of the four major histological tumor types of liver cancer is presented. Hepatocellular carcinoma, a malignant epithelial neoplasm that develops from hepatocytes, the basal liver parenchymal cells. Hepatoblastoma refers to a rare embryonic liver tumor arising from immature...

  • Extensive Hepatic Granulomas Associated with Peripheral T-Cell Lymphoma. Saito, Katsuhiko; Nakanuma, Yasuni; Ogawa, Shigehiko; Arai, Yoshiyuki; Hayashi, Morimoto // American Journal of Gastroenterology;Sep1991, Vol. 86 Issue 9, p1243 

    A case of T-cell lymphoma presenting with marked hepatosplenomegaly and extensive hepatic granulomas is described. A 55-yr-old female experienced long-term liver damage showing histological triaditis with atypical lymphoid cell infiltration and erythrophagocytosis. The patient developed marked...

  • The Preoperative Assessment of Hepatic Tumours: Evaluation of UK Regional Multidisciplinary Team Performance. Wiggans, M. G.; Jackson, S. A.; Fox, B. M. T.; Mitchell, J. D.; Aroori, S.; Bowles, M. J.; Armstrong, E. M.; Shirley, J. F.; Stell, D. A. // HPB Surgery;2013, p1 

    Introduction. In the UK, patients where liver resection is contemplated are discussed at hepatobiliary multidisciplinary team (MDT) meetings. The aim was to assess MDT performance by identification of patients where radiological and pathological diagnoses differed. Materials and Methods. A...

  • Liver Stem/Progenitor Cells in the Canals of Hering: Cellular Origin of Hepatocellular Carcinoma with Bile Duct Tumor Thrombi? Ningfu Peng; Lequn Li; Xiang Cai; Shaozao Tan; Ting Wu // Stem Cell Reviews & Reports;Dec2010, Vol. 6 Issue 4, p579 

    It is generally believed that the invasion of hepatocellular carcinoma (HCC) into the biliary tree ultimately leads to the formation of bile duct tumor thrombi (BDTT). However, recent studies revealed that primary tumor might be small, even undetectable, and there was no histopathologic evidence...

  • Multimodal Liver-Directed Management of Neuroendocrine Hepatic Metastases. Lewis, Mark A.; Hubbard, Joleen // International Journal of Hepatology;2011, p1 

    A preponderance of patients with neuroendocrine tumors (NETs) will experience hepatic metastases during the course of their disease. Many diagnoses of NETs are made only after the neoplasms have spread from their primary gastroenteropancreatic sites to the liver. This paper reviews current...

  • Induction of an EMT-like transformation and MET in vitro. Songming Ding; Wu Zhang; Zhiyuan Xu; Chunyang Xing; Haiyang Xie; Haijun Guo; Kanjie Chen; Penghong Song; Yu Gu; Fengqiang Xiao; Lin Zhou; Shusen Zheng // Journal of Translational Medicine;2013, Vol. 11 Issue 1, p1 

    Background: The epithelial-to-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET) play pivotal roles in metastasis of epithelial cancers. The distinction between them has shed new light on the molecular mechanisms of tumor metastasis. Recently, tumor microenvironment (TM)...

  • Hepatic Angiomyolipoma: Diagnostic Findings and Management. Kamimura, Kenya; Nomoto, Minoru; Aoyagi, Yutaka // International Journal of Hepatology;2012, p1 

    Angiomyolipoma (AML) is a benign mesenchymal tumor that is frequently found in the kidney and, rarely, in the liver. The natural history of hepatic AML has not been clarified, and, because of the similar patterns in imaging studies, such as ultrasonography, computed tomography, and magnetic...

  • Percutaneous image-guided radiofrequency ablation of liver tumors. Lencioni, Riccardo; Crocetti, Laura; Pina, Maria Clotilde Della; Cioni, Dania // Abdominal Imaging;Sep/Oct2009, Vol. 34 Issue 5, p547 

    The development of image-guided percutaneous techniques for local tumor ablation has been one of the major advances in the treatment of liver malignancies. Over the past two decades, several methods for chemical or thermal tumor destruction have been clinically tested. Among these methods,...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics