An electrical impedance tomography-based approach to monitor in vitro sodium chloride dissolution from pharmaceutical tablets

Rimpiläinen, Ville; Heikkinen, Lasse M.; Kuosmanen, Marko; Lehikoinen, Anssi; Voutilainen, Arto; Vauhkonen, Marko; Ketolainen, Jarkko
October 2009
Review of Scientific Instruments;Oct2009, Vol. 80 Issue 10, p103706
Academic Journal
An approach to monitor in vitro dissolution process from pharmaceutical tablets utilizing electrical impedance tomography (EIT) is introduced. In the demonstration, a tablet containing sodium chloride (NaCl) was dissolution tested using tap water as a dissolution medium within an apparatus similar to the United States Pharmacopoeia dissolution apparatus II. During the process, the three-dimensional sodium chloride concentration distribution was monitored with EIT measurements as a function of time. For EIT measurements, an array of electrodes was attached on the boundary of the dissolution vessel, a set of alternating electric currents was injected through the electrodes, and the resulting voltages were measured. With these data and by applying mathematical algorithms, an approximation for the spatial/temporal concentration distribution inside the vessel was computed. It was found that the computed distributions were relatively homogeneous. A NaCl release curve was computed by integrating the concentration distribution over the vessel volume, and the final value of the curve matched well with the reference point based on the weight loss of the tablet. Finally, EIT monitoring is suggested to be used for research and product development purposes.


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