Tethering Creates Unusual Kinetics for Ribosome-Associated Chaperones with Nascent Chains

Witt, Stephan N.
June 2009
Protein & Peptide Letters;Jun2009, Vol. 16 Issue 6, p631
Academic Journal
This article focuses on ribosome-associated chaperones. A chaperone bound close to the exit tunnel on a ribosome 25 Ã… from the emerging nascent chain has an effective concentration of 1 x 10-1 M, which is 4-5 orders of magnitude larger than the concentration of the chaperone in the cytosol. Ribosome-bound chaperones bind nascent chains intramolecularly with rates as large as 104 s-1 in order to keep chains unfolded.


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