Decreased expression of Neurensin-2 correlates with poor prognosis in hepatocellular carcinoma

Hai-Qing Ma; Xiao-Ting Liang; Jing-Jing Zhao; Hui Wang; Jian-Cong Sun; Yi-Bing Chen; Ke Pan; Jian-Chuan Xia; Saito, Hidetsugu; Tsubota, Akihito
October 2009
World Journal of Gastroenterology;10/14/2009, Vol. 15 Issue 38, p4844
Academic Journal
AIM: To investigate the expression of Neurensin-2 (NRSN2) in hepatocellular carcinoma (HCC) and its prognostic values in predicting survival. METHODS: The expression and prognostic significance of NRSN2 in HCC was examined by performing immunohistochemical analysis using a total of 110 HCC clinical tissue samples, and Western blotting analysis to further confirm the result. RESULTS: Decreased NRSN2 expression was shown in 70.9% cases. Loss of NRSN2 expression in HCC was significantly related to tumor size (P = 0.006). Larger tumor size was related to negative expression of NRSN2. Patients showing negative NRSN2 expression had a significantly shorter overall survival than those with positive expression (P = 0.008). Multivariate Cox regression analysis indicated that NRSN2 expression level was an independent factor of survival (P = 0.013). Western blotting analysis further confirmed decreased expression of NRSN2 in tumor tissues compared with non-tumorous tissues. CONCLUSION: Our study indicated that NRSN2 could be a tumor suppressor gene for HCC and a candidate biomarker for long-term survival in HCC.


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