TITLE

Effect of Lonicerae Flos extracts on reflux esophagitis with antioxidant activity

AUTHOR(S)
Sae-Kwang Ku; Bu-Il Seo; Ji-Ha Park; Gyu-Yeol Park; Young-Bae Seo; Jae-Soo Kim; Hyeung-Sik Lee; Seong-Soo Roh; Shimatani, Tomohiko
PUB. DATE
October 2009
SOURCE
World Journal of Gastroenterology;10/14/2009, Vol. 15 Issue 38, p4799
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
AIM: To observe the effects of traditional anti-inflammatory medicine Lonicerae Flos (LF) on rat reflux esophagitis (RE) induced by pylorus and forestomach ligation compared with the well-known proton antioxidant, α-tocopherol. METHODS: Rats were pretreated with three different dosages of LF (500, 250 and 125 mg/kg) orally, once a day for 14 d before pylorus and forestomach ligation. Nine hours after pylorus and forestomach ligation, changes to the stomach and esophagus lesion areas, gastric volumes, acid and pepsin outputs, antioxidant effects, esophageal lipid peroxidation, superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), myeloperoxidase and glutathione (GSH) levels, and collagen contents (marker of flexibility) were observed on the esophageal and fundic histopathology. The results were compared with an α-tocopherol (once orally, 1 h before operation, 30 mg/kg) treated group in which the effects on RE were already confirmed.
ACCESSION #
44838382

 

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