Portal hypertensive colopathy is associated with portal hypertension severity in cirrhotic patients

Diaz-Sanchez, Antonio; Nuñez-Martinez, Oscar; Gonzalez-Asanza, Cecilia; Matilla, Ana; Merino, Beatriz; Rincon, Diego; Beceiro, Inmaculada; Catalina, Maria Vega; Salcedo, Magdalena; Bañares, Rafael; Clemente, Gerardo; Mandell, Mercedes Susan
October 2009
World Journal of Gastroenterology;10/14/2009, Vol. 15 Issue 38, p4781
Academic Journal
AIM: To assess the prevalence of portal hypertension (PH) related colorectal lesions in liver transplant candidates, and to evaluate its association with the severity of PH. METHODS: Between October 2004 and December 2005, colonoscopy was performed in 92 cirrhotic liver transplant candidates. We described the lesions resulting from colorectal PH and their association with the grade of PH in 77 patients who underwent measurement of hepatic venous pressure gradient (HVPG). RESULTS: Mean age was 55 years and 80.7% of patients were men. The main etiology of cirrhosis was (PHC) was found in 23.9%, colonic varices in 7.6% and polyps in 38% of patients (adenomatous type 65.2%). One asymptomatic patient had a well-differentiated adenocarcinoma. The manifestations of colorectal PH were not associated with the etiology of liver disease or with the Child-Pugh grade. Ninety percent of patients with colopathy presented with gastroesophageal varices (GEV), and 27.5% of patients with GEV presented with colopathy (P = 0.12). A relationship between higher values of HVPG and presence of colopathy was observed (19.9 ± 6.2 mmHg vs 16.8 ± 5.4 mmHg, P = 0.045), but not with the grade of colopathy (P = 0.13). Preneoplastic polyps and neoplasm (P = 0.02) and spontaneous bacterial peritonitis (P = 0.006) were more prevalent in patients with colopathy. We did not observe any association between previous β-blocker therapy and the presence of colorectal portal hypertensive vasculopathy. CONCLUSION: PHC is common in cirrhotic liver transplant candidates and is associated with higher portal pressure.


Related Articles

  • Aetiology of paediatric portal hypertension - experience of a tertiary care centre in South India. Simon, Ebby G.; Joseph, A. J.; George, Biju; Zachariah, Uday G.; Jeyamani, R.; Eapen, C. E.; Chandy, George; Ramakrishna, B. S.; Kurian, George; Chacko, Ashok // Tropical Doctor;Jan2008, Vol. 39 Issue 1, p42 

    The aetiological profile of paediatric portal hypertension in our hospital, a tertiary care centre in South India, showed that the commonest causes were extrahepatic portal venous obstruction (EHPVO) and cirrhosis. Wilson's disease was the most common cause of cirrhosis.

  • Hepatic encephalomyelopathy: a complication following liver cirrhosis caused by Budd-Chiari syndrome and HBV. Jun Cheng; Shou-Wei Jiang; Zhong-Song Zhou; Qiu-Lin Sun // Journal of Infection in Developing Countries;Apr2014, Vol. 8 Issue 4, p551 

    Progressive encephalomyelopathy is a rare neurological complication of chronic liver disease, even manifesting progressive spastic paraparesis. Few reports detailing the clinical and diagnostic aspects of this uncommon cause of neurological deterioration in patients with hepatic insufficiency...

  • Idiopathic non-cirrhotic portal hypertension. CHEN Jie // Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi;Apr2013, Vol. 29 Issue 4, p311 

    The pathogenesis of idiopathic non-cirrhotic portal hypertension (INCPH) remains unknown and the disease is diagnosed by the absence of recognized clinical indicators of cirrhosis and of any other known etiologies of portal hypertension. To promote understanding of this disease, a comprehensive...

  • CORELAÅ¢II CLINICO-ECOGRAFICE ÃŽN HIPERTENSIUNEA PORTALÄ‚. Melinte-Popescu, M.; Bălan, G. // Jurnalul de Chirurgie;2012, Vol. 8 Issue 1, p31 

    Portal hypertension is the main cause of complications of hepatic diseases determining portosystemic collateral circulation, ascites and gastroesophageal varices. The aim of the current study was to establish a correlation between clinical signs and ultrasound aspects of portal hypertension....

  • Acute upper gastrointestinal bleeding in liver cirrhosis patients. Svoboda, Pavel; Konecny, Michal; Martinek, Arnost; Hrabovsky, Vladimir; Prochazka, Vlastimil; Ehrmann, Jiri // Biomedical Papers of the Medical Faculty of Palacky University i;Sep2012, Vol. 156 Issue 3, p266 

    Objectives. This study focuses on the etiology of acute upper gastrointestinal (GIT) bleeding in liver cirrhosis patients. Methods. A prospective examination of 137 liver cirrhosis patients with acute upper GIT bleeding. All patients underwent endoscopic examination and in the case of multiple...

  • A study of aetiology of portal hypertension in adults (including the elderly) at a tertiary centre in southern India. Goel, Ashish; Madhu, Kadiyala; Zachariah, Uday; Sajith, K. G.; Ramachandran, Jeyamani; Ramakrishna, Banumathi; Gibikote, Sridhar; Jude, John; Chandy, George M.; Elias, Elwyn; Eapen, C. E. // Indian Journal of Medical Research;May2013, Vol. 137 Issue 5, p922 

    Background & objectives: There are only a few studies on aetiology of portal hypertension among adults presenting to tertiary care centres in India; hence we conducted this study to assess the aetiological reasons for portal hypertension in adult patients attending a tertiary care centre in...

  • Breast Cancer Developed in a Male Patient With Liver Cirrhosis Bearing Hepatocellular Carcinoma. Yoneda, Satoshi; Yoshikawa, Masahide; Yamane, Yoshiko; Nakatani, Toshiya; Iwasawa, Shu; Nishimura, Kimio; Watanabe, Iwao; Fukui, Hiroshi; Enoki, Noburu // American Journal of Gastroenterology;Feb2000, Vol. 95 Issue 2, p556 

    Presents the case study of a 55-year-old Japanese man with liver cirrhosis complicated with hepatocellular carcinoma, who developed breast cancer. Findings of the physical examination on the patient; Factors that played an important etiological role in the development of breast cancer in men.

  • Classification of Cirrhosis. Galambos, John T. // American Journal of Gastroenterology;Dec1975, Vol. 64 Issue 6, p437 

    Presents information on the classification of cirrhosis. Morphologic classification; Etiologic classification; Functional classification.

  • Bladder Varices Caused by Portal Hypertension. Zhang, Yushi; Li, Hanzhong; Wang, Dong; Yang, Xue // Cell Biochemistry & Biophysics;Jul2015, Vol. 72 Issue 3, p795 

    This report presents a rare case of bladder varices caused by portal hypertension in a patient with no past history of surgery. The objective is to describe the diagnosis and management of such cases. A 63-year-old man with a 7-month history of intermittent painless gross hematuria and a 9-year...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics