Animal models for the gastrointestinal motility evaluation

Merwid-Ląd, Anna; Trocha, Małgorzata; Ksiądzyna, Dorota; Sozański, Tomasz; Szeląg, Adam
May 2009
Gastroenterologia Polska / Gastroenterology;2009, Vol. 16 Issue 3, p201
Academic Journal
Animal models for the digestive tract motility disorders still remain in the centre of interest of many investigators. Experimental studies on animals have obvious advantages like the availability of the subjects, ability to perform invasive tests or extensive tissue sampling. Small rodents such as mice and rats are the most commonly used animals. The ideal animal model should be simple, inexpensive, not labor-intensive and capable of detecting either stimulation or inhibition of the digestive tract motility. Methods used to assess the gastrointestinal motility in laboratory animals consist mainly of the measurement of the gastric myoelectrical activity, gastric emptying, migrating motor complex, intestinal transit and motility of the large intestine. While selecting the most suitable model and particular species of experimental animals, great interspecies variables should be taken into consideration. Additionally, results obtained in animals may differ greatly in comparison with human subjects, therefore final conclusions should be cautiously translated from preclinical to clinical studies.


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