Angiogenic study in Graves' disease treated with thyroid arterial embolization

Zhao, Wei; Gao, Bu-Lang; Liu, Zhi-Yong; Yi, Gen-Fa; Shen, Li-Juan; Yang, Hui-Ying; Li, Hong; Song, Dian-Ping; Jiang, Yong-Neng; Hu, Ji-Hong; Luo, Gang
October 2009
Clinical & Investigative Medicine;Oct2009, Vol. 32 Issue 5, pE335
Academic Journal
Purpose: To investigate angiogenesis in the thyroid of Graves' disease (GD) treated with thyroid arterial embolization through analysis of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and microvessel density (MVD). Materials and methods: Forty-two GD patients were treated with thyroid arterial embolization and followed up for 1-68 months after embolization. Before embolization and at 7 days, 3, 6, 12, 36 and 48 months following embolization, TT3, TT4, FT3, FT4, TSH and thyroid stimulating antibody (TSAb) were tested respectively. Thyroid biopsy was performed under the guidance of computed tomography for immunohistochemical staining of VEGF and bFGF, and MVD within the thyroid gland was marked by CD34. Results: VEGF and bFGF were mostly expressed in the cytoplasm and on the cell membrane. The expression of VEGF was increased (P<0.05) at =6 months compared with before embolization and decreased (P<0.05) at ⩾1 year compared with either at ⩽6 months or before embolization. The expression of bFGF was not statistically different at ⩽6 months compared with before embolization but was decreased (P <0.05) at =1 year compared with either at ⩽6 months or before embolization. Thyroid MVD marked by CD34 had similar changes to those of the VEGF expression after embolization. There was a positive correlation between VEGF and bFGF (P <0.05) and between VEGF or bFGF and MVD (P <0.05). Thyroid hormones mostly returned to normal and TSAb was decreased in longer follow-up. Conclusion: Thyroid arterial embolization can decrease the expression of VEGF, bFGF and MVD. Consequently, angiogenesis within the GD thyroid will be decreased in the long term after embolization and may serve as the basis for reduced thyroid size and function.


Related Articles

  • Delta-Like 4/Notch Pathway Is Differentially Regulated in Benign and Malignant Thyroid Tissues. Geers, Caroline; Colin, Ides M.; Gérard, Anne-Catherine // Thyroid;Dec2011, Vol. 21 Issue 12, p1323 

    Background: Angiogenesis plays an essential role in embryonic and tumoral developments. Vascular endothelial growth factor (VEGF), one of the best known proangiogenic factors, is increased in thyroid cancers, especially in papillary carcinomas (PC). However, other regulating mechanisms refine...

  • Upregulation of Endocrine Gland-Derived Vascular Endothelial Growth Factor in Papillary Thyroid Cancers Displaying Infiltrative Patterns, Lymph Node Metastases, and BRAFMutation. Daniela Pasquali; Angela Santoro; Pantaleo Bufo; Giovanni Conzo; William J Deery; Andrea Renzullo; Giacomo Accardo; Valentina Sacco; Antonio Bellastella; Giuseppe Pannone // Thyroid;Apr2011, Vol. 21 Issue 4, p391 

    Background:Endocrine gland-derived vascular endothelial growth factor (Prok1) and prokineticin 2 (Prok2) are involved in the organ-specific regulation of angiogenesis, which is a crucial step toward cancer progression in most tumors, including those of thyroid gland. The oncogene BRAFV600E...

  • Clinicopathological findings of retinal angiomatous proliferation. Akiyuki Kawamura; Ryuzaburo Mori; Mitsuko Yuzawa // Graefe's Archive of Clinical & Experimental Ophthalmology;Feb2007, Vol. 245 Issue 2, p295 

    AbstractBackground??Neovascular membranes obtained from surgical excision of neovascularization for retinal angiomatous proliferation (RAP) were examined histopathologically in an attempt to elucidate the pathogenic mechanism of RAP.Methods??Nine eyes of eight patients (mean age, 79?6?years) who...

  • F-FDG PET and biomarkers for tumour angiogenesis in early breast cancer. Groves, Ashley; Shastry, Manu; Rodriguez-Justo, Manuel; Malhotra, Anmol; Endozo, Raymondo; Davidson, Timothy; Kelleher, Tina; Miles, Kenneth; Ell, Peter; Keshtgar, Mohammed // European Journal of Nuclear Medicine & Molecular Imaging;Jan2011, Vol. 38 Issue 1, p46 

    Purpose: Tumour angiogenesis is an independent and strong prognostic factor in early breast carcinoma. We performed this study to investigate the ability of F-FDG to detect angiogenesis in early breast carcinoma using PET/CT. Methods: Twenty consecutive patients with early (T1-T2) breast...

  • VEGF EXPRESSION AND MICROVESSEL DENSITY IN GASTRIC CARCINOMAS. Stanculescu, Diana; Simionescu, Cristiana; Georgescu, Claudia; Margaritescu, Cl.; Muntean, Mihaela // Annals of the Romanian Society for Cell Biology;2011, Vol. 16 Issue 2, p188 

    The angiogenesis is one of the most important factors in tumor development and dissemination. We aimed to evaluate the angiogenesis and its involvement in gastric carcinomas natural history, based on immunohistochemical expression of vascular endothelial growth factor and tumor microvessel...

  • Drug Targets to Pro-Angiogenetic Factors with Special Reference to Primary Peritoneal Mesothelioma. Ranieri, Girolamo; Ruggieri, Eustachio; Falco, Gaetano; Zizzo, Nicola; Mattioli, Eliseo; Francesco Zito, Alfredo; Patruno, Rosa; Gasparini, Giampietro // Endocrine, Metabolic & Immune Disorders - Drug Targets;Sep2006, Vol. 6 Issue 3, p271 

    Angiogenesis is necessary for growth and the spread of human tumors. Animal studies also suggest that angiogenesis is an important interspecies biological mechanism of tumor development. Angiogenesis is a complex multistep cascade modulated by both positive soluble factors, such as vascular...

  • Stromal interaction essential for vascular endothelial growth factor A-induced tumour growth via transforming growth factor-β signalling. Weidenaar, A C; ter Elst, A; Kampen, K R; Meeuwsen-de Boer, T G J; de Jonge, H J M; Scherpen, F J G; den Dunnen, W F A; Kamps, W A; de Bont, E S J M // British Journal of Cancer;12/6/2011, Vol. 105 Issue 12, p1856 

    Background:High vascular endothelial growth factor (VEGFA) levels at the time of diagnosis confer a worse prognosis to multiple malignancies. Our aim was to investigate the role of VEGFA in promoting tumour growth through interaction with its environment.Methods:HL-60 cells were transduced with...

  • The soluble fragment of VE-cadherin inhibits angiogenesis by reducing endothelial cell proliferation and tube capillary formation. Li, H.; Shi, X.; Liu, J.; Hu, C.; Zhang, X.; Liu, H.; Jin, J.; Opolon, P.; Vannier, J.-P.; Perricaudet, M.; Janin, A.; Soria, C.; Lu, H. // Cancer Gene Therapy;Oct2010, Vol. 17 Issue 10, p700 

    Vascular endothelial-specific cadherin (VE-cadherin) is an endothelial cell-specific adhesion molecule, localized at cell-cell contact sites. It is involved in physiological and pathological angiogenesis. In this study, we showed that in vitro a soluble N-terminal fragment of VE-cadherin (EC1-3)...

  • The role of tissue factor pathway inhibitor-2 in malignant transformation of sinonasal inverted papilloma. Yu, Huapeng; Liu, Quan; Wang, Huan; Wang, Dehui; Hu, Li; Sun, Xicai; Liu, Juan // European Archives of Oto-Rhino-Laryngology;Aug2014, Vol. 271 Issue 8, p2191 

    The aim was to evaluate the potential role of tissue factor pathway inhibitor-2 (TFPI-2) in the process of malignant transformation of sinonasal inverted papilloma (SIP). We evaluated the expression of TFPI-2 in 23 SIP and 8 SIP with squamous cell carcinoma (IPcSCC), compared to 9 normal...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics