TITLE

Cardiac troponin in the intensive care unit

AUTHOR(S)
Lim, Wendy
PUB. DATE
October 2009
SOURCE
Clinical & Investigative Medicine;Oct2009, Vol. 32 Issue 5, pE405
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose: Cardiac troponin is specific to the myocardium and is a useful biomarker for the diagnosis of myocardial infarction. Detection of elevated blood levels of troponin indicates damage to myocardial cells, but does not indicate the mechanism. Causes other than acute coronary syndromes and myocardial infarction can result in troponin elevation and these conditions frequently occur in critically ill patients in the intensive care unit. The interpretation, clinical significance and appropriate management of an elevated troponin measurement in critically ill patients are uncertain. Source: Studies evaluating the prevalence of troponin elevation among medical-surgical intensive care unit patients, and its prognostic significance with regards to adverse outcomes will be reviewed. Conclusions: Cardiac troponin elevation is common and observed in 40 to 50% of critically ill medical and surgical patients. Elevated levels appear to identify patients at increased risk for death in the intensive care unit or hospital setting. This finding, and its relation to myocardial infarction and acute coronary syndromes, requires prospective study to better understand the implications for diagnosis and management.
ACCESSION #
44809939

 

Related Articles

  • Diagnostic and prognostic impact of copeptin and high-sensitivity cardiac troponin T in patients with pre-existing coronary artery disease and suspected acute myocardial infarction. Potocki, Mihael; Reichlin, Tobias; Thalmann, Simone; Zellweger, Christa; Twerenbold, Raphael; Reiter, Miriam; Steuer, Stephan; Bassetti, Stefano; Drexler, Beatrice; Stelzig, Claudia; Freese, Michael; Winkler, Katrin; Haaf, Philip; Balmelli, Cathrin; Hochholzer, Willibald; Osswald, Stefan; Mueller, Christian // Heart;Apr2012, Vol. 98 Issue 7, p558 

    Objective The early diagnosis of acute myocardial infarction (AMI) can be particularly challenging in patients with known coronary artery disease (CAD) due to pre-existing ECG changes and chronic increases in cardiac troponin (cTn) levels Design Of 1170 consecutive patients presenting with...

  • Correlating infarct size and patient prognosis: are cardiac biomarkers truly insufficient?: reply. Lønborg, Jacob; Engstrøm, Thomas // European Heart Journal - Cardiovascular Imaging;Sep2013, Vol. 14 Issue 9, p932 

    A response from the authors of the article "Final infarct size measured by cardiovascular magnetic resonance in patients with ST elevation myocardial infarction predicts long-term clinical outcome: an observational study" published in a 2013 issue is presented.

  • Correlating infarct size and patient prognosis: are cardiac biomarkers truly insufficient? Shah, Benoy Nalin // European Heart Journal - Cardiovascular Imaging;Sep2013, Vol. 14 Issue 9, p932 

    A letter to the editor is presented in response to the article "Final infarct size measured by cardiovascular magnetic resonance in patients with ST elevation myocardial infarction predicts long-term clinical outcome: an observational study" by J. Lonborg and colleagues in a 2013 issue.

  • More appropriate study design is need for confirm diagnostic utility of S100A4 protein. Cekirdekci, Elif I. // European Review for Medical & Pharmacological Sciences;Nov2015, Vol. 19 Issue 22, p4212 

    A letter to the editor is presented in response to the article "Serum S100A4 Levels As a Novel Biomarker for Detection of Acute Myocardial Infarction" by X. J. Gong et al. that was published in a 2015 issue.

  • Using cardiac enzymes and markers in acute MI. Berry, John; Conti, C. Richard // Patient Care;7/30/2000, Vol. 34 Issue 14, p12 

    Discusses the use of cardiac enzymes and markers to improve the diagnosis and prognosis of suspected acute myocardial infarction (MI). Inclusion of the measurement of creatine kinase (CK), its isoenzyme CK-MB and cardiac troponins; Necrotic activity of myocytes as an acute MI progresses; Time...

  • Negative high-sensitivity troponin rules out AMI.  // South African Family Practice;Oct2012, Vol. 54 Issue 5, p421 

    The article offers a brief summary of a study that examined whether initially undetectable high-sensitivity troponin can effectively rule-out acute myocardial infarction (AMI). Findings show that high-sensitivity troponin T assay (hs-cTnT) has a very high-sensitivity of up to 100 percent. AMI...

  • How low can we go: high-sensitivity troponin T in patients presenting with chest pain. Schneider, Hans G. // Annals of Clinical Biochemistry;May2011, Vol. 48 Issue 3, p198 

    The author reflects on the use of troponin measurement in the diagnosis of acute myocardial infarction (AMI). The author says that AMI requires detection of the rise and fall of a cardiac biomarker above 99th percentile as the cut off point from using older assays. Furthermore, a study which...

  • CONFIRMATION OF DIAGNOSIS AND EXCLUSION OF MYOCARDIAL INFARCTION BY TROPONIN T AND CK-MB. RUS, MARIUS; CIOARĂ, FELICIA LIANA; COSTESCU, CRISTIAN ILIE // Acta Medica Transilvanica;sep2014, Vol. 19 Issue 3, p199 

    The study showed that among patients admitted with suspected acute coronary syndrome, whose symptoms resolved following 24 hours, the diagnosis of myocardial infarction can be eliminated if the TnT remains ≤ 0.10 ng / l for 12-24 hours and CK-MB ≤5.0 ng / l up to 10-12 hours of onset...

  • Dual-cardiac marker capillary waveguide fluoroimmunosensor based on tyramide signal amplification. Niotis, Aristeidis E.; Mastichiadis, Christos; Petrou, Panagiota S.; Christofidis, Ion; Kakabakos, Sotirios E.; Siafaka-Kapadai, Athanasia; Misiakos, Konstantinos // Analytical & Bioanalytical Chemistry;Feb2010, Vol. 396 Issue 3, p1187 

    The early diagnosis of acute myocardial infarction requires the determination of several markers in serum shortly after its incidence. The markers most widely employed are the isoenzyme MB of creatine kinase (CK-MB) and the cardiac troponin I (cTnI). In the present work, a capillary waveguide...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics