TITLE

Arrhythmic effects of Ivabradine in patients with coronary artery disease

AUTHOR(S)
Murat, Sani N.; Orcan, Salih; Akdemir, Ramazan; Dogan, Mehmet; Kara, Emel; Balci, Mustafa
PUB. DATE
October 2009
SOURCE
Clinical & Investigative Medicine;Oct2009, Vol. 32 Issue 5, pE322
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objectives: Ivabradine is the first specific heart ratelowering agent that has completed clinical development for stable angina pectoris. The aim of the present study was to investigate the effects of ivabradine therapy on P-wave duration, dispersion and QT duration, dispersion in coronary artery disease patients. Methods and Results: The study population consisted of 21 patients with CAD who have confirmed by coronary angiography previously. Written informed consent was obtained in all patients. Twelve-lead electrocardiogram was recorded for each subject at a rate of 50mm/s on admission and repeated after 1 month ivabradine therapy. QT duration, QT dispertion, maximum and minimum QT duration calculated. Maximum and minimum P wave and P wave dispersion has been calculated. Heart rate was decreased after ivabradine therapy. (75±15 and 63±10, P=0.02).There was no difference between Pmax, Pmin and Pdis values before and after treatment. QTmax value was prolonged after treatment. (410±43 and 431±14, P=0,005) but there was no difference between cQTmax value.(455±38 and 439±21) There was no difference between QTdis and cQTdis values before and after treatment. (44±18 & 49±14; and 49±22 & 48±15). QTmax was prolonged after ivabradine therapy but cQTmax, Pdis, QTdis and cQTdis were not prolonged. Conclusion: There is no relationship between ivabradine therapy and increased risk of ventricular and atrial arrhythmia in coronary artery disease patient.
ACCESSION #
44809931

 

Related Articles

  • Coronary Artery Bypass Grafting Is Associated with a Significant Worsening of QT Dynamicity and Heart Rate Variability. Yavuz, Bunyamin; Duman, Umit; Abali, Gulcan; Dogan, Omer Faruk; Yazicioglu, Alkin; Sahiner, Levent; Aytemir, Kudret; Tokgozoglu, Lale; Demircin, Metin; Nazli, Nasih; Kabakci, Giray; Oto, Ali // Cardiology;2006, Vol. 106 Issue 1, p51 

    Background: Imbalance in autonomic nervous system and impaired myocardial repolarization has been shown to increase the risk for arrhythmias in patients with coronary artery disease. This study evaluated the effects of coronary artery bypass grafting (CABG) on heart rate variability and QT...

  • Coronary artery spasm and ventricular arrhythmias. Looi, Khang Li; Grace, Andrew; Agarwal, Sharad // Postgraduate Medical Journal;Aug2012, Vol. 88 Issue 1042, p465 

    Coronary artery spasm (CAS) is characterised by chest pain at rest and transient ST segment elevation on the ECG. The natural history of variant angina is not fully understood. Patients with CAS are younger, mostly female subjects and usually do not have traditional cardiovascular risk factors...

  • Utility and prognostic value of exercise stress testing in post revascularization patients. Gherasim, Daniel; Moise, Bianca; Apetrei, Eduard // Romanian Journal of Cardiology;2014, Vol. 24 Issue 4, p278 

    Exercise testing (ET) is a well-established, safe an cost-eff ectiveness procedure which is widely used in clinical practice for many decades for detection of coronary artery disease (CAD). The mean test sensitivity and specificity are not very high and are lower than the values for the most...

  • Structure and Mechanics of Supporting Cells in the Guinea Pig Organ of Corti. Zetes, Deborah E.; Tolomeo, Jason A.; Holley, Matthew C. // PLoS ONE;Nov2012, Vol. 7 Issue 11, Special section p1 

    The mechanical properties of the mammalian organ of Corti determine its sensitivity to sound frequency and intensity, and the structure of supporting cells changes progressively with frequency along the cochlea. From the apex (low frequency) to the base (high frequency) of the guinea pig cochlea...

  • THE EFFECT OF OBESITY ON PROARRHYTHMIC ATRIAL REMODELING IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE UNDERGOING ELECTIVE CORONARY ARTERY BYPASS GRAFTING. Alkora-Ioana, Balan; Irina, Pintilie; Cristina, Somkereki; Marcel, Perian; Constantin, Şerban Răzvan; Alina, Scridon // Acta Medica Marisiensis;2019 Supplement, Vol. 65, p6 

    Background: Obesity is recognized as an important atrial fibrillation (AF) risk factor. Objective: We aimed to evaluate the impact of obesity on atrial proarrhythmic remodeling in patients with stable coronary artery disease (CAD) undergoing elective coronary artery bypass grafting (CABG)....

  • Does 16-MDCT angiography scanning direction affect image quality of coronary artery bypass grafts and the native coronary arteries? Hazirolan, Tuncay; Turkbey, Baris; Karcaaltincaba, Musturay; Akata, Deniz; Sahiner, Levent; Aytemir, Kudret; Oto, M. Ali; Balkanci, Ferhun; Besim, Aytekin // European Radiology;Jan2007, Vol. 17 Issue 1, p97 

    To assess the impact of scanning direction on the image quality of coronary artery bypass grafts (CABGs), native coronary arteries (NCAs) were examined by electrocardiographically (ECG) gated 16-row multidetector computed tomography (16-MDCT). Eighty-two patients with 209 grafts were studied by...

  • The Effect of T'ai Chi Exercise on Autonomic Nervous Function of Patients with Coronary Artery Disease. Chang, Rei-Yeuh; Koo, Malcolm; Yu, Zer-Ran; Kan, Chung-Ben; Chu, I-Tseng; Hsu, Chen-Tung; Chen, Cheng-Yun // Journal of Alternative & Complementary Medicine;Nov2008, Vol. 14 Issue 9, p1107 

    Objective: The objective of this study was to evaluate the effect of t'ai chi (TC) on heart rate variability (HRV) from baseline to 9 months in patients with coronary artery disease (CAD). Design: A comparative trial was undertaken comparing the acute and long-term effect of TC on HRV in...

  • Father fights back over school age admission policy. Morton, Katy // Nursery World (Haymarket Business Publications Ltd);6/11/2012, Vol. 112 Issue 4295, p4 

    The article reports that Stefan Richter, a father of three children, is calling for flexibility in the schools admission system in Great Britain. He wants to defer the school entry of his two-year-old daughter to enable her to start reception after her fifth birthday at the end of August 2012....

  • Extensive myocardial ‘fatty-metaplasia’ 20-years post-myocardial infarction. Chen, Zhong; Kapetanakis, Stam; Carr-White, Gerry; Rinaldi, C. Aldo; Chiribiri, Amedeo // European Heart Journal - Cardiovascular Imaging;Apr2013, Vol. 14 Issue 4, p396 

    Clinical image is presented for extensive adipose deposition in the chronic infarct region of a 61-year-old man with previous anterior myocardial infarction and recent coronary bypass surgery.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics