MAb Production is Specific for Human Zona Pellucida Glycoproteins

October 2009
Fertility Weekly;10/6/2009, p8
Academic Journal
The article presents a study which analyzes the human zona pellucida (ZP) expression in follicles during different developmental stages. Study shows no staining for monoclonal antibodies (MA)-1620 against human ZP2 in resting primordial follicles but has seen weak staining in growing follicles. The authors conclude that there is a development of specific murine MAbs against human ZPs.


Related Articles

  • Sperm-Specific Factors Implicated in Oolemma Binding and / or Fusion. Redkar, A.A. // Current Genomics;Jun2001, Vol. 2 Issue 2, p141 

    In mammals, a key event in the process of fertilization occurs when a sperm binds to and fuses with the oocyte plasma membrane (oolemma). However, information regarding the genetic and molecular bases of this complex process of sperm-oolemma penetration (SOP) is limited. Research to elucidate...

  • Putting early human development into the 4 dimension. Albertini, David // Journal of Assisted Reproduction & Genetics;Sep2012, Vol. 29 Issue 9, p859 

    No abstract available.

  • In Vitro maturation rate of oocytes collected from indigenous cows of Assam after slaughter. Deka, S. S.; Kalita, D. J.; Sarma, S.; Dutta, D. J. // Indian Journal of Animal Research;Dec2015, Vol. 49 Issue 6, p869 

    Sixty healthy ovaries were collected from local slaughter house. Oocytes from small and medium sized follicles (2-8 mm in diameter) were selected for oocyte collection using aspiration followed by slicing . A and B category ( cumulus oocyte complexes (COCs) with more than 5 layers and 3-5 layers...

  • Hyperosmotic Condition Improves Zona Pellucida Binding of Sperm. Liu, D.Y. // Fertility Weekly;4/10/2006, p6 

    The article cites key findings from Australia indicating that zona pellucida binding ability is significantly increased by the incubation of sperm in hyper-osmotic media. Osmolality is found to have significant effects on the acrosome reaction in vitro, capacitation, sperm motility and calcium...

  • Human sperm bound to the zona pellucida have normal nuclear chromatin as assessed by acridine orange fluorescence. D.Y. Liu; H.W.G. Baker // Human Reproduction;Jun2007, Vol. 22 Issue 6, p1597 

    BACKGROUND The aim of this study was to determine if only sperm with double stranded DNA could bind to the human zona pellucida (ZP). METHODS Sperm samples from 124 infertile men with a range of semen abnormalities were studied. Oocytes that had failed to fertilize in IVF or ICSI were used for...

  • Developmental competence of immature oocytes aspirated from ovarian antral follicles as a method for fertility preservation. Safian F.; Khalili M. A.; Karimi Zarchi M.; Mohsenzadeh M.; Ashourzadeh S. // Iranian Journal of Reproductive Medicine;Apr2015 Supplement, p80 

    Introduction: Advances in the treatment of cancerous women in reproductive age have markedly been increased recently. Also, in vitro maturation (IVM) of immature oocytes collected from ovary has been proposed for fertility preservation. In addition, the morphology of oocytes post IVM is one of...

  • Carbohydrate analysis of the zona pellucida and cortical granules of human oocytes by means of ultrastructural cytochemistry. María Jiménez-Movilla; Manuel Avilés; María José Gómez-Torres; Pedro José Fernández-Colom; María Teresa Castells; Joaquín de Juan; Alberto Romeu; José Ballesta // Human Reproduction;Aug2004, Vol. 19 Issue 8, p1842 

    BACKGROUND: The zona pellucida (ZP), the mammalian oocyte coat, consists of a restricted number of highly glycosylated proteins. In vitro sperm binding studies suggest a higher binding affinity for the outer region of the ZP compared to its inner region in different species. However, the reason...

  • Detection of zona pellucida proteins during human folliculogenesis. Debra A. Gook; D.H. Edgar; J. Borg; M. Martic // Human Reproduction;Feb2008, Vol. 23 Issue 2, p394 

    BACKGROUND The stage of folliculogenesis at which the human zona pellucida (ZP) is initiated and the cells responsible for the origin of the ZP continue to be controversial. This study characterizes the development of the ZP during human folliculogenesis using ovarian samples donated from...

  • Harmful to Normal Development of Mouse Follicles and Oocytes. Calongos, Gianna // Fertility Weekly;8/3/2009, p2 

    The article attempts to examine the research "Harmful Effects of Anti-Zona Pellucida Antibodies in Folliculogenesis, Oogenesis and Fertilization," by Giannina Calongos and colleagues, published in the "Journal of Reproductive Immunology." According to the study, anti-zona pellucida (anti-ZP)...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics