TITLE

The plasticity of human telomeres demonstrated by a hypervariable telomere repeat array that is located on some copies of 16p and 16q

AUTHOR(S)
Coleman, Joanna; Baird, Duncan M.; Royle, Nicola J.
PUB. DATE
September 1999
SOURCE
Human Molecular Genetics;Sep99, Vol. 8 Issue 9, p1637
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Studies the plasticity of human telomeres demonstrated by a hypervariable telomere repeat array located on some copies of 16p and 16q regions of the chromosome. Influence of telomerase activity on telomere repeats at the proximal end of the array; Distribution of subterminal repeat sequences on human chromosomes; Formation of telomeres adjacent to the expressed sequence tag-like sequence.
ACCESSION #
4473334

 

Related Articles

  • Allele-specific relative telomere lengths are inherited. Graakjaer, Jesper; Der-Sarkissian, Héra; Schmitz, Annette; Bayer, Jan; Thomas, Gilles; Kolvraa, Steen; Londoño-Vallejo, José-Arturo // Human Genetics;Apr2006, Vol. 119 Issue 3, p344 

    Previous studies have indicated that single relative telomere lengths are defined in the zygote. In order to explore the possibility that single telomere lengths segregate in families, we compared relative telomere lengths obtained from allelic chromosome extremities transmitted from parent to...

  • The human CST complex is a terminator of telomerase activity. Chen, Liuh-Yow; Redon, Sophie; Lingner, Joachim // Nature;8/23/2012, Vol. 488 Issue 7412, p540 

    The lengths of human telomeres, which protect chromosome ends from degradation and end fusions, are crucial determinants of cell lifespan. During embryogenesis and in cancer, the telomerase enzyme counteracts telomeric DNA shortening. As shown in cancer cells, human telomerase binds the...

  • The hTERTα Splice Variant is a Dominant Negative Inhibitor of Telomerase Activity. Colgin, Lorel M; Wilkinson, Christen; Englezou, Anna; Kilian, Andrzej; Robinson, Murray O; Reddel, Roger R // Neoplasia;Oct2000, Vol. 2 Issue 5, p426 

    The telomerase catalytic subunit (hTERT) is an essential component of the holoenzyme complex that adds telomeric repeats to the ends of human chromosomes. Maintenance of telomeres by telomerase or another mechanism is required for cell immortalization, and loss of telomeric DNA has been proposed...

  • Telomere maintenance without telomerase. Lundblad, Victoria // Oncogene;1/21/2002 Review, Vol. 21 Issue 4, p522 

    Recombination-dependent maintenance of telomeres, first discovered in budding yeast, has revealed an alternative pathway for telomere maintenance that does not require the enzyme telomerase. Experiments conducted in two budding yeasts, S. cerevisiae and K. lactis, have shown recombination can...

  • Effects of reconstitution of telomerase activity on telomere maintenance by the alternative lengthening of telomeres (ALT) pathway. Grobelny, Jennifer V.; Kulp-McEliece, Michelle; Broccoli, Dominique // Human Molecular Genetics;Sep2001, Vol. 10 Issue 18, p1953 

    Telomere length maintenance is essential for cellular immortalization, and thus tumorigenesis. Most human tumors and immortal cell lines maintain their telomeric DNA via the activity of a specialized reverse transcriptase, telomerase. Stabilization of telomeric repeat tracts may also be achieved...

  • Telomerase suppression by chromosome 6 in a human papillomavirus type 16-immortalized keratinocyte cell line and in a cervical cancer cell line. Steenbergen, Renske D.M.; Kramer, Debbie; Meijer, Chris J.L.; Walboomers, Jan M.M.; Trott, Deborah A.; Cuthbert, Andrew P.; Newbold, Robert F.; Overkamp, Wilhelmina J.I.; Zdzienicka, Malgorzata Z.; Snijders, Peter J.F.; Steenbergen, R D; Kramer, D; Meijer, C J; Walboomers, J M; Trott, D A; Cuthbert, A P; Newbold, R F; Overkamp, W J; Zdzienicka, M Z; Snijders, P J // JNCI: Journal of the National Cancer Institute;6/6/2001, Vol. 93 Issue 11, p865 

    Background: High-risk human papillomavirus (HPV) types play a major role in the development of cervical cancer in vivo and can induce immortalization of primary human keratinocytes in vitro. Activation of the telomere-lengthening enzyme telomerase constitutes a key event in both...

  • Telomere Lengths and Telomerase Activity in Dog Tissues: A Potential Model System to Study Human Telomere and Telomerase Biology. Nasir, Lubna; Devlin, Pauline; McKevitt, Tom; Rutteman, Gerard; Argyle, David J // Neoplasia;Jul2001, Vol. 3 Issue 4, p351 

    Studies on telomere and telomerase biology are fundamental to the understanding of aging and age-related diseases such as cancer. However, human studies have been hindered by differences in telomere biology between humans and the classical murine animal model system. In this paper, we describe...

  • Alternative lengthening of telomeres is associated with chromosomal instability in osteosarcomas. Scheel, Christina; Schaefer, Karl-Ludwig; Jauch, Anna; Keller, Monika; Wai, Daniel; Brinkschmidt, Christian; van Valen, Frans; Boecker, Werner; Dockhorn-Dworniczak, Barbara; Poremba, Christopher // Oncogene;6/28/2001, Vol. 20 Issue 29, p3835 

    Telomere maintenance is regarded as a key mechanism in overcoming cellular senescence in tumor cells and in most cases is achieved by the activation of telomerase. However there is at least one alternative mechanism of telomere lengthening (ALT) which is characterized by heterogeneous and...

  • Endometriosis is associated with aberrant endometrial expression of telomerase and increased telomere length. D.K. Hapangama; M.A. Turner; J.A. Drury; S. Quenby; G. Saretzki; C. Martin-Ruiz; T. Von Zglinicki // Human Reproduction;Jul2008, Vol. 23 Issue 7, p1511 

    BACKGROUND In order to test our hypothesis that endometriosis is associated with abnormal expression of telomerase and telomere lengthening in endometrium, we assessed endometrial expression of the human telomerase enzyme and telomere length (TL). METHODS This prospective pilot study, included...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics