Neuronal activity in the globus pallidus internus in patients with tics

Zhuang, P.; Hallett, M.; Zhang, X.; Li, J.; Zhang, Y.; Li, Y.
October 2009
Journal of Neurology, Neurosurgery & Psychiatry;Oct2009, Vol. 80 Issue 10, p11
Academic Journal
Objective: To explore the role of neuronal activity in the globus pallidus internus (GPi) in the generation of tic movements. Methods: 8 patients with Tourette's syndrome with medically intractable tics who underwent a unilateral pallidotomy for severe tics were studied. They ranged in age from 17 to 24 years; disease duration was 7-19 years. Microelectrode recording was performed in the GPi. The electromyogram (EMG) was simultaneously recorded in muscle groups appropriate for the patient's tics. The relationship between neuronal firing pattern and the EMG was studied. Results: 232 neurons were recorded during tics from eight trajectories. Of these neurons, in addition to decreased neuronal firing rate and irregular firing pattern, 105 (45%) were tic related showing either a burst of activity or a pause in ongoing tonic activity. They could be synchronous (n = 75), earlier than EMG onset (n = 27) or following EMG onset (n = 3). The GPi neuronal bursts preceded EMG onset with decreased (n = 6) or increased activity (n = 21). The initial change in neural activity occurred about 50 ms to 2 s before the EMG onset. Conclusions: Although the data are descriptive and preliminary, the tic related neuronal activity observed in GPi appears to indicate that the basal ganglia motor circuit is involved in tic movements. The early neuronal activity seen in GPi may reflect premonitory sensations that precede a tic.


Related Articles

  • The neurophysiological correlates of motor tics following focal striatal disinhibition. McCairn, Kevin W.; Bronfeld, Maya; Belelovsky, Katya; Bar-Gad, Izhar // Brain: A Journal of Neurology;Aug2009, Vol. 132 Issue 8, p2125 

    The cortico-basal ganglia pathway is involved in normal motor control and implicated in multiple movement disorders. Brief repetitive muscle contractions known as motor tics are a common symptom in several basal ganglia related motor disorders. We used focal micro-injections of the GABA-A...

  • Long-term Outcome of Globus Pallidus Internus Deep Brain Stimulation in Patients With Tourette Syndrome. Jian-Guo Zhang; Yan Ge; Stead, Matt; Kai Zhang; Shuang-shuang Yan; Wei Hu; Fan-Gang Meng // Mayo Clinic Proceedings;Nov2014, Vol. 89 Issue 11, p1506 

    Objective: To evaluate the effectiveness of deep brain stimulation (DBS) of the globus pallidus internus (GPi) on tic severity and common comorbidities in patients with severe Tourette syndrome that is refractory to pharmacological treatment and psychotherapy. Patients and Methods: We...

  • External globus pallidus stimulation modulates brain connectivity in Huntington's disease. Ligot, Noémie; Krystkowiak, Pierre; Simonin, Clémence; Goldman, Serge; Peigneux, Philippe; Van Naemen, John; Monclus, Michel; Lacroix, Simon Frédéric; Devos, David; Dujardin, Kathy; Delmaire, Christine; Bardinet, Eric; Delval, Arnaud; Delliaux, Marie; Defebvre, Luc; Yelnik, Jerome; Blond, Serge; Destée, Alain; De Tiège, Xavier // Journal of Cerebral Blood Flow & Metabolism;Jan2011, Vol. 31 Issue 1, p41 

    Positron emission tomography with O-15-labeled water was used to study at rest the neurophysiological effects of bilateral external globus pallidus (GPe) deep brain stimulation in patients with Huntington's disease (HD). Five patients were compared with a control group in the on and off states...

  • Axonal branching patterns of ventral pallidal neurons in the rat. Tripathi, Anushree; Prensa, Lucía; Mengual, Elisa // Brain Structure & Function;Sep2013, Vol. 218 Issue 5, p1133 

    The ventral pallidum (VP) is a key component of the cortico-basal ganglia circuits that process motivational and emotional information, and also a crucial site for reward. Although the main targets of the two VP compartments, medial (VPm) and lateral (VPl) have already been established, the...

  • Firing rates of pallidal neurons are similar in Huntington’s and Parkinson’s disease patients. Tang, Joyce K. H.; Moro, Elena; Lozano, Andres M.; Lang, Anthony E.; Hutchison, William D.; Mahant, Neil; Dostrovsky, Jonathan O. // Experimental Brain Research;Oct2005, Vol. 166 Issue 2, p230 

    According to the now classical basal ganglia–thalamocortical circuitry model, the chorea of Huntington’s disease (HD) and the hypokinesia in Parkinson’s disease (PD) are explained by a decrease in the inhibitory output (reduced firing rates) from the globus pallidus internus...

  • Neural responses in multiple basal ganglia regions during spontaneous and treadmill locomotion tasks in rats. Shi, L. H.; Luo, F.; Woodward, D. J.; Chang, J. Y. // Experimental Brain Research;Aug2004, Vol. 157 Issue 3, p303 

    To investigate the role of basal ganglia in locomotion, a multiple-channel, single-unit recording technique was used to record neural activity simultaneously in the dorsal lateral striatum (STR), globus pallidus (GP), subthalamic nucleus (STN) and substantia nigra pars reticulata (SNr) during...

  • In vivo Exploration of the Connectivity between the Subthalamic Nucleus and the Globus Pallidus in the Human Brain Using Multi-Fiber Tractography. Pujol, Sonia; Cabeen, Ryan; Sébille, Sophie B.; Yelnik, Jérôme; François, Chantal; Vidal, Sara Fernandez; Karachi, Carine; Yulong Zhao; Cosgrove, G. Rees; Jannin, Pierre; Kikinis, Ron; Bardinet, Eric // Frontiers in Neuroanatomy;1/19/2017, Vol. 10, p1 

    The basal ganglia is part of a complex system of neuronal circuits that play a key role in the integration and execution of motor, cognitive and emotional function in the human brain. Parkinson's disease is a progressive neurological disorder of the motor circuit characterized by tremor,...

  • Emotion disrupts neural activity during selective attention in psychopathy. Sadeh, Naomi; Spielberg, Jeffrey M.; Heller, Wendy; Herrington, John D.; Engels, Anna S.; Warren, Stacie L.; Crocker, Laura D.; Sutton, Bradley P.; Miller, Gregory A. // Social Cognitive & Affective Neuroscience;Mar2013, Vol. 8 Issue 3, p235 

    Dimensions of psychopathy are theorized to be associated with distinct cognitive and emotional abnormalities that may represent unique neurobiological risk factors for the disorder. This hypothesis was investigated by examining whether the psychopathic personality dimensions of...

  • AAV–BDNF mediated attenuation of quinolinic acid-induced neuropathology and motor function impairment. Kells, A. P.; Henry, R. A.; Connor, B. // Gene Therapy;Jul2008, Vol. 15 Issue 13, p966 

    Maintenance and plasticity of striatal neurons is dependant on brain-derived neurotrophic factor (BDNF), which is depleted in the Huntington's disease striatum due to reduced expression and disrupted corticostriatal transportation. In this study we demonstrate that overexpression of BDNF in the...


Read the Article


Sign out of this library

Other Topics