The validity of a biomarker method for indirect detection of gastric mucosal atrophy versus standard histopathology

Leja, Marcis; Kupcinskas, Limas; Funka, Konrads; Sudraba, Agnese; Jonaitis, Laimas; Ivanauskas, Audrius; Janciauskas, Dainius; Kiudelis, Gediminas; Chiu, Han-Mo; Lin, Jaw-Town
November 2009
Digestive Diseases & Sciences;Nov2009, Vol. 54 Issue 11, p2377
Academic Journal
journal article
Background: Atrophy of the stomach mucosa is considered to be premalignant lesion for gastric cancer development; easy identification of this condition from a blood-sample would allow identifying the group of individuals at increased risk for cancer development.Aims: The objective of the current study was to validate a biomarker method (pepsinogen I/II ratio and gastrin-17) for indirect detection of atrophy of the stomach mucosa versus standard histopathology in Caucasian and Asian populations.Methods: Altogether, 241 patients aged 55 and above referred for upper endoscopy due to dyspeptic symptoms (125 from Latvia, 76 from Lithuania, and 40 from Taiwan) were enrolled. Pepsinogen I, pepsinogen II, gastrin-17 (the latter after stimulation with protein-rich meal) and IgG/IgA antibodies to Helicobacter pylori infection were determined by ELISA method; standard histopathology according to the updated Sydney classification read by two independent expert pathologists was used for the comparison.Results: Pepsinogen I/II ratio below 3 was well related to atrophy (moderate to severe) in the corpus part of the stomach (P < 0.0001) with 83.3% sensitivity and 87.1% specificity. Gastrin-17 below 5 pmol/L was related to atrophy in the antral part (P = 0.007) with 36.8% sensitivity and 86.5% specificity.Conclusions: Decreased pepsinogen I/II ratio is a reliable marker for atrophy in the corpus, and may be recommended for identification of individuals with this type of atrophy. The utility of gastrin-17 for the detection of atrophy in the antral part of the stomach still requires further evaluation due to the low sensitivity.


Related Articles

  • Associated Factors of Atrophic Gastritis Diagnosed by Double-Contrast Upper Gastrointestinal Barium X-Ray Radiography: A Cross-Sectional Study Analyzing 6,901 Healthy Subjects in Japan. Yamamichi, Nobutake; Hirano, Chigaya; Shimamoto, Takeshi; Minatsuki, Chihiro; Takahashi, Yu; Nakayama, Chiemi; Matsuda, Rie; Fujishiro, Mitsuhiro; Konno-Shimizu, Maki; Kato, Jun; Kodashima, Shinya; Ono, Satoshi; Niimi, Keiko; Mochizuki, Satoshi; Tsuji, Yosuke; Sakaguchi, Yoshiki; Asada-Hirayama, Itsuko; Takeuchi, Chihiro; Yakabi, Seiichi; Kakimoto, Hikaru // PLoS ONE;Oct2014, Vol. 9 Issue 10, p1 

    Background: Double-contrast upper gastrointestinal barium X-ray radiography (UGI-XR) is one of the most widely conducted gastric cancer screening methods. It has been executed to find gastric cancer, but has not been usually executed to detect premalignant atrophic mucosa of stomach. To...

  • Accuracy of pepsinogens for early diagnosis of atrophic gastritis and gastric cancer in Iranian population. Zoalfaghari, Abbas; Aletaha, Najmeh; Roushan, Nader; Taslimi, Reza; Foroutan, Hossein; Faridnia, Bita // Medical Journal of the Islamic Republic of Iran;2014, Vol. 28, p1 

    Background: Currently, non-invasive methods for screening atrophic gastritis and gastric cancer are lacking. The purpose of this study was to evaluate the value of serological parameters including serum pepsinogen I (PGI), pepsinogen II (PGII) and pepsinogen I: II ratio for the screening...

  • 18F-FDG uptake in the stomach on screening PET/CT: value for predicting Helicobacter pylori infection and chronic atrophic gastritis. Shigeki Kobayashi; Mayumi Ogura; Naohisa Suzawa; Noriyuki Horiki; Masaki Katsurahara; Toru Ogura; Hajime Sakuma // BMC Medical Imaging;10/18/2016, Vol. 16, p1 

    Background: The aim of this study was to determine the value of 18F-FDG uptake on screening PET/CT images for the prediction of Helicobacter pylori (H. pylori) infection and chronic atrophic gastritis. Methods: Among subjects who underwent 18F-FDG PET/CT for cancer screening from April 2005 to...

  • Determination of whether screening tests for chronic atrophic gastritis really has a positive predictive value. PAOLA, FLAVIANO DI; D'ANGELO, VALENTINA; TATANGELO, FABIANA; BARCHIESI, VITTORIA; RIZZO, MARIANNA; CANTILE, MONICA; BOTTI, GERARDO; CAVALCANTI, ERNESTA // Molecular Medicine Reports;2015, Vol. 12 Issue 3, p3521 

    Intestinal-type gastric adenocarcinomas are preceded by precancerous lesions, which begin with chronic atrophic gastritis. Over the last few years, multiple serological screening techniques have been performed and commercialized for the diagnosis of chronic atrophic gastritis. In the present...

  • Topography of gastric damage in H. pylori infection: evaluation by serum pepsinogens levels. Cavallaro, L.G.; Moussa, A.M.; Seghini, P.; Aragona, G.; Iori, V.; Cavestro, G.M.; Dal Bò, N.; Pilotto, A.; Leandro, G.; Di Mario, F. // Gut;Sep2002 Supplement 2, Vol. 51, pA29 

    Background: Helicobacter pylori infection is characterized by activity in gastric mucosa. Serum pepsinogen I (sPGI) and II (sPGII) have been proposed a "serological biopsies "of gastric mucosa and resulted altered in Hp infection. Aim: To evaluate sPGI and sPGII levels in relation to the...

  • Scheduled endoscopic surveillance controls secondary cancer after curative endoscopic resection for early gastric cancer: a multicentre retrospective cohort study by Osaka University ESD study group. Motohiko Kato; Tsutomu Nishida; Katsumi Yamamoto; Shiro Hayashi; Shinji Kitamura; Takamasa Yabuta; Toshiyuki Yoshio; Takeshi Nakamura; Masato Komori; Naoki Kawai; Akihiro Nishihara; Fumihiko Nakanishi; Masanori Nakahara; Hideharu Ogiyama; Kazuo Kinoshita; Takuya Yamada; Hideki Iijima; Masahiko Tsujii; Tetsuo Takehara // Gut;Oct2013, Vol. 62 Issue 10, p1425 

    Background After endoscopic submucosal dissection (ESD) of early gastric cancer (EGC), patients are at high risk for synchronous or metachronous multiple gastric cancers. Objective To elucidate the time at which multiple cancers develop and to determine whether scheduled endoscopic surveillance...

  • Helicobacter pylori Infection and Serum Pepsinogen A, Pepsinogen C, and Gastrin in Gastritis and Peptic Ulcer: Significance of Inflammation and Effect of Bacterial Eradication. Wagner, Siegfried; Haruma, Ken; Gladziwa, Ulrich; Soudah, Bisharah; Gebel, Michael; Bleck, Jörg; Schmidt, Hartmut; Manns, Michael // American Journal of Gastroenterology;Aug1994, Vol. 89 Issue 8, p1211 

    Objectives: To study the relationship between Helicobacter pylori infection, gastric inflammatory scores, and fasting gastrin and pepsinogen A and C concentrations, and to evaluate the effect of treatment on these parameters. Methods: Gastrin and pepsinogen A and C concentrations were measured...

  • CagA Pozitif Helikobakter pilori enfeksiyonunda serum oksidatif stres durumu. Asiltürk, Zeliha; Nazlıgül, Yaşar; Yıldız, Mehmet; Küçükazman, Metin; Bulur, Oktay; Tezer, Ayla; Çizmeci, Zeynep; Akın, Kadir Okhan // Journal of Clinical & Experimental Investigations / Klinik ve De;2011, Vol. 2 Issue 2, p202 

    Objectives: Previous studies have suggested that CagA positive Helicobacter pylori (H.pylori) infection may cause the various oxidative damages. The objective of this study was to investigate serum oxidative status in infectetion with CagA positive H.pylori strains. Materials and methods:...

  • Case-control study of Epstein-Barr virus and Helicobacter pylori serology in Latin American patients with gastric disease. Cárdenas-Mondragón, M G; Torres, J; Flores-Luna, L; Camorlinga-Ponce, M; Carreón-Talavera, R; Gomez-Delgado, A; Kasamatsu, E; Fuentes-Pananá, E M // British Journal of Cancer;6/9/2015, Vol. 112 Issue 12, p1866 

    Background:Chronic tissue damage induced by Helicobacter pylori (HP)-driven inflammation is considered the main risk of gastric carcinoma (GC). Epstein-Barr virus (EBV) infection has also been associated with GC. In this study, we aim to address the role of EBV in inflammatory GC precursor...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics