TITLE

Review: Steroid avoidance or withdrawal does not increase mortality or graft loss in kidney transplant patients

AUTHOR(S)
Nosrati, Mordechai Saeid; Pascual, J.
PUB. DATE
September 2009
SOURCE
ACP Journal Club;9/22/2009, Vol. 151 Issue 3, p8
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article presents the findings of a study regarding the efficacy and safety of steroid avoidance in kidney transplant recipients. The research evaluated steroid avoidance or withdrawal, with one group randomized to steroid avoidance or withdrawal after more than two weeks of treatment in patients receiving a kidney transplant. The study revealed that steroid avoidance or withdrawal increases risk for acute graft rejection but does not increase mortality.
ACCESSION #
44638107

 

Related Articles

  • Severe Early Rejection Predicts Graft Outcome.  // Kidney;Jan/Feb98, Vol. 7 Issue 1, p32 

    Assesses the impact on graft survival of rejection episodes (RE) during the first year post renal transplantation. Long-term graft survival rates; Lack of effect of benign RE during the first year after transplant on long-term kidney graft outcome.

  • The impact of FTY720 (fingolimod) on vasodilatory function and arterial elasticity in renal transplant patients. Timm H. Westhoff; Sven Schmidt; Petra Glander; Lutz Liefeld; Sebastian Martini; Gerd Offermann; Hans H. Neumayer; Walter Zidek; Markus van der Giet; Klemens Budde // Nephrology Dialysis Transplantation;Aug2007, Vol. 22 Issue 8, p2354 

    Background. FTY720 has recently demonstrated a similar efficacy in prevention of acute graft rejection compared with mycophenolate mofetil (MMF) in a large phase III trial of de novo renal transplant recipients. Creatinine clearance, however, was significantly lower in FTY720-treated patients....

  • The role of angiotensin II type 1 receptor-activating antibodies in renal allograft vascular rejection. Dragun, Duska // Pediatric Nephrology;Jul2007, Vol. 22 Issue 7, p911 

    Acute rejection with vascular involvement remains a challenging problem in renal allotransplantation. Fibrinoid necrosis of the arteries with secondary thrombotic occlusions is C4d negative in 50% of cases and has the worst prognosis among all allograft vascular lesions. Nonhuman leukocyte...

  • Rejecting rejection. ROGERS, DIANE // Stanford Medicine;May2010, p6 

    The article offers the case study of a 29 year old woman who had a successful kidney transplant. She had her first four-hour infusion of a desensitization drug, intravenous immunoglobulin which was designed to lower the number of organ-rejecting antibodies in patients. It mentions that she still...

  • FNAB by Flow Cytometry: A Rapid, Safe Diagnostic Tool.  // Kidney;Jan/Feb98, Vol. 7 Issue 1, p31 

    Tests the hypothesis that fine-needle aspiration biopsy samples in conjunction with peripheral blood lymphocyte analysis by flow cytometry more reliably diagnosed acute rejection in kidney transplant patients. Observed differences from several lymphocyte subpopulations on FNAB; Obtained values...

  • Pretransplant Cell-Mediated Lympholysis Correlates with Chronic Rejection/Graft Failure.  // Kidney;Jan/Feb98, Vol. 7 Issue 1, p31 

    Assesses whether cell-mediated cytotoxicity (CML) predicted chronic rejection in kidney transplantation. Prevalence rate of chronic rejection; Association between pretransplant cytotoxic T-lymphocyte activity and chronic rejection and graft failure in halpoidentical pediatric patients.

  • CD14[sup +] Cells Increased in Acute Rejections.  // Kidney;Jan/Feb98, Vol. 7 Issue 1, p32 

    Studies the activity of CD14[sup +] cells in acute graft rejections in kidney transplantation, determined by fine-needle aspiration biopsy (FNAB). Presence of monocytes-macrophages and cytokines/chemokines in FNAB cultures. Presence of CD14[sup +] cells in steroid-resistant acute rejections...

  • Immunological induction with thymoglobulin: reduction in the number of doses in renal transplant from deceased donor. Moura, Lucio Roberto Requião; Tonato, Eduardo José; Ferraz, Érika Arruda; Filliponi, Thiago Corsi; Chinen, Rogério; Matos, Ana Cristina Carvalho; da Silva, Maurício Rodrigues Fregonesi; de Souza Durão, Marcelino; Pacheco-Silva, Alvaro // Einstein (16794508);Jan-Mar2011, Vol. 9 Issue 1, p56 

    Objective: To compare three different regimens of thymoglobulin induction. Methods: One hundred seventy two patients submitted to renal transplantation from a dead donor were divided into three groups according to the total number of thymoglobulin doses used in the post-transplantation surgery:...

  • Adding MMF Reduces CsA Dose with No Increase in Acute Rejection.  // Kidney;Jul/Aug99, Vol. 8 Issue 4, p166 

    Tests the hypothesis that adding mycophenolate mofetil (MMF) reduces cyclosporine (CsA) dose with no increase in acute rejection following renal transplantation. Impact of CsA dose reduction in association with MMF on renal function and transforming growth factor-beta[sub 1] in long-term kidney...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics