Review: Combining 2 classes of blood pressure-lowering drugs has an approximately additive effect on systolic blood pressure

Shantsila, Alena; Lip, Gregory Y. H.; Wald, D. S.
August 2009
ACP Journal Club;8/18/2009, Vol. 151 Issue 2, p9
Academic Journal
The article reports that combining 2 classes of blood pressure lowering drugs has an approximately additive effect on systolic blood pressure. In the trials, mean placebo-subtracted systolic BP reductions for monotherapies ranged from 6.8 mm Hg for ACE-Is to 9.3 mm Hg for BBsand reductions for drug combinations ranged from 13.9 mm Hg for ACE-I combinations to 18.9 mm Hg for BB combinations


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