TITLE

Homocysteine, Folate and Vitamin B12 Concentrations in Middle Aged Adults Presenting with Sensorineural Hearing Impairment

AUTHOR(S)
Gocer, Celil; Genc, Umut; Eryilmaz, Adil; Islam, Ahmet; Boynuegri, Suleyman; Bakira, Fatih
PUB. DATE
October 2009
SOURCE
Journal of International Advanced Otology;2009, Vol. 5 Issue 3, p340
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: Aim of this study was to investigate a possible association between hearing impairment and homocysteine, folate and vitamin B12 concentrations in subjects presenting with sensorineural hearing loss before the geriatric age, namely before the age of 60. Materials and Methods: Pure tone audiometry was performed and the age expected deviations were calculated according the ISO 7029. Two groups of patients were studied, one (n=78) with hearing impairment, and a control group (n=53), matched in age, without hearing impairment. Results: In blood, mean concentration of vitamin B12 was lower in the hearing impairment group (251.7 +/- 158.6 pg/ml, mean +/- SD) than in the control group (304.9 +/- 152.0 pg/ml, p=0.004); folate concentration was also lower in patients with hearing impairment (7.26 +/- 3.25 ng/ml) compared to controls (8.29 +/- 3.11 ng/ml, p=0.029), whereas homocystein was higher (hearing impairment: 16.59 +/- 5.15 μmol/ml; control: 13.69 +/- 4.61 μmol/ml, p=0.001). Conclusion: In both groups, no correlation between the age and the blood concentrations of vitamin B12, folate and homocysteine could be found. Our findings suggest that elevated homocystein and decreased folate and vitamin B12 concentrations accompany to hearing loss before the geriatric age.
ACCESSION #
44523849

 

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