Synthesis of isotopomers of l-DOPA and dopamine labeled with hydrogen isotopes in the side chain

Pająk, M.; Kańska, M.
September 2009
Journal of Radioanalytical & Nuclear Chemistry;Sep2009, Vol. 281 Issue 3, p365
Academic Journal
The enzymatic synthesis of three isotopomers of l-DOPA labeled with deuterium and tritium at α carbon atom was elaborated. These compounds were converted into [(1 S)-2H]–, [(1 S) -3H]–, and doubly labeled [(1 S)-2H/3H]-dopamines using enzyme tyrosine decarboxylase. Doubly labeled (1 R) isotopologue, i.e., [(1 R)-2H/3H]-dopamine, was afforded by enzymatic decarboxylation of authentic l-DOPA carried out in deuteriated and tritiated incubation medium.


Related Articles

  • Solid-phase synthesis of deuterium- and tritium-labeled dopamine using carbon nanomaterials. Shevchenko, V.; Nagaev, I.; Shevchenko, K.; Chernysheva, M.; Badun, G.; Fedoseev, V.; Myasoedov, N. // Radiochemistry;Jun2011, Vol. 53 Issue 3, p336 

    Various procedures for preparing dopamine labeled with deuterium (H) and tritium (H) were considered. The labeled dopamine into which the hydrogen isotopes were introduced by solid-phase halogenation contained, on the average, 2.8 H (H) atoms. The labeled dopamine prepared by solid-phase isotope...

  • Enzymatic synthesis of dopamine ring labeled with hydrogen isotopes. Pająk, M.; Kańska, M. // Journal of Radioanalytical & Nuclear Chemistry;Feb2009, Vol. 279 Issue 2, p455 

    The synthesis of two isotopomers of L-DOPA, the precursors for labeled dopamine is reported. The ring labeled with deuterium or tritium [2′,5′,6-2H3]-L-DOPA, and [2′,5′,6-3H3]-L-DOPA were obtained using acid catalyzed isotopic exchange between L-DOPA and heavy or...

  • Measurements of fuel and shell areal densities of OMEGA capsule implosions using elastically scattered protons. Frenje, J. A.; Li, C. K.; Séguin, F. H.; Kurebayashi, S.; Petrasso, R. D.; Soures, J. M.; Delettrez, J.; Glebov, V. Yu.; Meyerhofer, D. D.; Radha, P. B.; Roberts, S.; Sangster, T. C.; Skupsky, S.; Stoeckl, C. // Physics of Plasmas;Nov2002, Vol. 9 Issue 11, p4719 

    Implosions of capsules filled with small quantities of deuterium–tritium (DT) were studied using up to seven proton spectrometers on the OMEGA laser system [T. R. Boehly et al., Opt. Commun. 133, 495 (1997)]. Simultaneous measurements of elastically scattered protons, i.e.,...

  • Fusion under the spotlight. Coppinger, Rob // Engineer (00137758);11/21/2003, Vol. 292 Issue 7640, p14 

    No abstract available.

  • Ion cyclotron range of frequencies heating and flow generation in deuterium-tritium plasmas. Wilson, J.R.; Bell, R.E. // Physics of Plasmas;May98, Vol. 5 Issue 5, p1721 

    Examines radio-frequency heating on the Tokamak Fusion Test Reactor. Emphasis on pressure and current profile control in deuterium-tritium (DT) plasmas; Investigation of pressure control using ion Bernstein wave heating; Observation of plasma heating and driven poloidal flows; Factors to...

  • Electron affinity of hydrogen, deuterium, and tritium: A nonadiabatic variational calculation... Kinghorn, Donald B.; Adamowicz, Ludwik // Journal of Chemical Physics;3/15/1997, Vol. 106 Issue 11, p4589 

    Reports on nonadiabatic variational calculations for the anion ground state energies, mass shifts and electron affinities of hydrogen, deuterium and tritium. Electron affinity values of the three elements obtained using a basis of explicitly correlated Gaussians; Prediction of exact...

  • Tritium concentration measurements in the Joint European Torus divertor by optical spectroscopy... Hillis, D.L.; Morgan, P.D.; Ehrenberg, J.K.; Groth, M.; Stamp, M.F.; von Hellermann, M.; Kumar, V. // Review of Scientific Instruments;Jan1999, Vol. 70 Issue 1, p359 

    Focuses on the development of a diagnostic technique to measure the deuterium-tritium isotopic ratio in the divertor of the Joint European Torus tokamak with a species-selective Penning vacuum gauge. Source of electrons; Proportionality of the observed line emission intensity to the partial...

  • Investigation of tritium pathways in the Joint European Torus (JET) tokamak. Hillis, D. L.; Hogan, J. T.; Andrew, P.; Coad, J. P.; Ehrenberg, J. K.; Groth, M.; Houlberg, W. A.; von Hellermann, M.; Horton, L. D.; Matthews, G. F.; Monk, R. D.; Morgan, P. D.; Stamp, M. F.; Zastrow, K-D. // Physics of Plasmas;May99, Vol. 6 Issue 5, p1985 

    The neutral tritium concentration in the subdivertor region of JET [P.-H. Rebut, R. J. Bickerton, and B. E. Keen, Nucl. Fusion 25, 1011 (1985)] is measured during deuterium-to-tritium changeover experiments with a novel species-selective Penning gauge coupled to a high-resolution spectrometer....

  • Clarification.  // Nature;9/25/2014, Vol. 513 Issue 7519, p472 

    A clarification to the graphic in the news feature "The fusion upstarts" in the 2014 issue is presented which omitted to note that the deuterium–deuterium reaction has a 50% chance of producing tritium and a proton.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics