TITLE

The comparative responsiveness of the EQ-5D and SF-6D to change in patients with inflammatory arthritis

AUTHOR(S)
Harrison, M. J.; Davies, L. M.; Bansback, N. J.; McCoy, M. J.; Verstappen, S. M. M.; Watson, K.; Symmons, D. P. M.
PUB. DATE
November 2009
SOURCE
Quality of Life Research;Nov2009, Vol. 18 Issue 9, p1195
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Comparative evidence regarding the responsiveness of the EQ-5D and SF-6D in arthritis patients is conflicting and insufficient across the range of disease severity. We examined the comparative responsiveness of the EQ-5D and SF-6D in cohorts of patients with early inflammatory disease through to severe rheumatoid arthritis (RA). Responsiveness was tested using the effect size (ES) and standardised response mean (SRM). Correlation of change in EQ-5D and SF-6D with disease specific measures was tested using Pearson correlations and the Steiger’s Z test. Treatment response and self-reported change were used as anchors of important change. The EQ-5D was more responsive to deterioration (ES ratio (EQ-5D/SF-6D): 1.6–3.0) and the SF-6D more responsive to improvement (ES ratio (SF-6D/EQ-5D): 1.1–1.8) in health. The SF-6D did not respond well to deterioration in patients with established severe RA (ES and SRM 0.08). The EQ-5D provided larger absolute mean change estimates but with greater variance compared to the SF-6D. The comparative responsiveness of the EQ-5D and SF-6D differs according to the direction of change. The level of mean change of the EQ-5D relative to the SF-6D has implications for cost-effectiveness analysis. Use of the SF-6D in patients with severe progressive disease may be inappropriate.
ACCESSION #
44513499

 

Related Articles

  • The reporting quality of studies investigating the diagnostic accuracy of anti-CCP antibody in rheumatoid arthritis and its impact on diagnostic estimates. Zintzaras, Elias; Papathanasiou, Afroditi A.; Ziogas, Dimitrios C.; Voulgarelis, Michael // BMC Musculoskeletal Disorders;2012, Vol. 13 Issue 1, p113 

    Background: Recently anti-CCP testing has become popular in the diagnosis of rheumatoid arthritis (RA). However, the inadequate reporting of the relevant diagnostic studies may overestimate and bias the results, directing scientists into making false decisions. The aim of the present study was...

  • Short- and medium-term results of the thrust plate prosthesis in patients with polyarthritis. Fink, Bernd; Siegmüller, Claas; Schneider, Thomas; Conrad, Silke; Schmielau, Gudrun; Rüther, Wolfgang // Archives of Orthopaedic & Trauma Surgery;May2000, Vol. 120 Issue 5/6, p294 

    The thrust plate prosthesis is an implant with metaphyseal fixation to the proximal femur, which leaves the diaphyseal bone untouched. Therefore, this implant is preferred in younger patients. It is dependent on good bone quality in the proximal femur. Because the bone quality is reduced in...

  • Dose-related patterns of glucocorticoid-induced side effects.  // International Journal of Advances in Rheumatology;2009, Vol. 7 Issue 4, p135 

    In this study of glucocorticoid-related health problems in rheumatoid arthritis (RA) patients, such problems were observed to increase either linearly or in a threshold-dependent manner (i.e. become apparent at a certain glucocorticoid dosage) with doses used in long-term treatment of RA. The...

  • Perceived functional disabilities among rheumatoid arthritis patients. Tuominen, Risto; Tuominen, Sini; Suominen, Carita; Möttönen, Timo; Azbel, Michael; Hemmilä, Joonas // Rheumatology International;Mar2010, Vol. 30 Issue 5, p643 

    The aim of this study was to determine from patient perspective the most relevant physical functions when estimating the functional disabilities, and to estimate the perceived relative influence of them. Structured telephone interviews were conducted among 143 RA patients. The subjects were...

  • Temporomandibular Joint Pressure Pain Threshold Is Systemically Modulated in Rheumatoid Arthritis. Alstergren, Per; Fredriksson, Lars; Kopp, Sigvard // Journal of Orofacial Pain;Summer2008, Vol. 22 Issue 3, p231 

    Aims: To investigate the relative importance of systemic and local inflammatory mediators (serotonin: 5-HT; tumor necrosis factor: TNF; soluble interleukin-1 receptor II: IL-1sRII) in the modulation of temporomandibular joint (TMJ) pressure pain threshold in patients with seropositive or...

  • A Rare Case of Primary Ovarian Lymphoma in Patients With Rheumatoid Arthritis: Can We Attribute This to Tumor Necrosis Factor Inhibitors? Thota, Swapna; Manda, Sudhir; Dahbar, Mazen; Daw, Hameed // Clinical Ovarian Cancer;Nov2009, Vol. 2 Issue 2, p121 

    Ovarian involvement as an initial manifestation of lymphoma is a rare occurrence. A literature search reveals that the current knowledge is limited to few case reports. Recently it has been suggested that the use of tumor necrosis factor inhibitors (TNFIs) is associated with increased incidence...

  • Rheumatoid Arthritis. Emery, Paul; Suarez-Almazor, Maria E. // American Family Physician;11/1/2003, Vol. 68 Issue 9, p1821 

    Presents information about rheumatoid arthritis. Effects of treatments; Definition; Incidence and prevalence; Prognosis.

  • CITATIONS AND CLINICIANS' NOTES: RHEUMATOID ARTHRITIS.  // Current Medical Literature: Rheumatology;2005, Vol. 24 Issue 1, p14 

    Presents citations and clinician's notes on rheumatoid arthritis. Inducement of anticardiolipin antibodies in treating patients with rheumatoid arthritis with tumor necrosis factor alpha antagonists; Discussion on the prolonged efficacy of etanercept in refractory enthesitis-related arthritis;...

  • Rheumatoid Arthritis Induced by α-Interferon Therapy. Passos de Souza, E.; Teles Evangelista Segundo, P.; Freire José, F.; Lemaire, D.; Santiago, M. // Clinical Rheumatology;Jul2001, Vol. 20 Issue 4, p297 

    : Interferon (IFN) therapy has been used for the treatment of common diseases such as hepatitis C, myeloproliferative disorders, autoimmune diseases and various types of cancer. Given the biological properties of interferon, it is not surprising that there are a larger number of side effects due...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics