TITLE

Fibrolamellar Hepatocellular Carcinoma

AUTHOR(S)
Liu, Shu; Chan, Kwok Wah; Wang, Bingyuan; Qiao, Liang
PUB. DATE
October 2009
SOURCE
American Journal of Gastroenterology;Oct2009, Vol. 104 Issue 10, p2617
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Fibrolamellar hepatocellular carcinoma (FHLCC) generally occurs in young individuals lacking a background of chronic liver disease and other risk factors for hepatocellular carcinoma. The clinical presentations of FLHCC are generally nonspecific, and the α-fetoprotein level is typically within the normal range in most cases. Imaging studies have a major role in clinical diagnosis, but pathology is the gold standard in confirming diagnosis. Pathological characteristics of FLHCC include the presence of tumor cells with a deeply eosinophilic cytoplasm and macronucleoli surrounded by abundant fibrous bands. The most effective treatment for FLHCC is aggressive surgical resection. This comprehensive literature review gives a full account of the clinical, pathological, and molecular features of FLHCC.
ACCESSION #
44461518

 

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