Na+/H+ exchanger is required for hyperglycaemia-induced endothelial dysfunction via calcium-dependent calpain

Shuangxi Wang; Qisheng Peng; Junhua Zhang; Liying Liu
November 2008
Cardiovascular Research;Nov2008, Vol. 80 Issue 2, p255
Academic Journal
Aims: Recent studies have reported that the calcium-dependent protease calpain is involved in hyperglycaemia-induced endothelial dysfunction and that the Na+/H+ exchanger (NHE) is responsible for an increase in the intracellular calcium (Ca2+i) concentration in diabetes. We hypothesized that activation of NHE mediates hyperglycaemia-induced endothelial dysfunction via calcium-dependent calpain.


Related Articles

  • Endothelial Dysfunction in Diabetes. AVOGARO, ANGELO; ALBIERO, MATTIA; MENEGAZZO, LISA; DE KREUTZENBERG, SAULA; FADINI, GIAN PAOLO // Diabetes Care;May2011 Supplement 2, Vol. 34, pS285 

    The article outlines the mechanisms of endothelial dysfunction in diabetes, the role of endothelial progenitor cells (EPC) in cardiovascular homeostasis and the implications of EPC alterations in diabetes. Due to the adverse effects of hyperglycemia and oxidative stress on vascular biology,...

  • Calcium Intake and 25-Hydroxyvitamin D Are Associated with Hyperglycemia in an Adult South Florida Population. Florez, Hermes; Apaza, Ana; Alejandro, Angel R.; Sosa, Andrea; Denham, Misha; Hollis, Bruce; Roos, Bernard; Levis, Silvina // Diabetes;Jun2007 Supplement 1, Vol. 56, pA18 

    Previous studies have shown a relationship between low levels of 25-hydroxy-vitamin D (25-OH-VitD) and glucose intolerance, but the effect that calcium intake has on this relation is less clear. Therefore we evaluated the association of daily calcium intake and hypovitaminosis D with fasting...

  • Simultaneous Control of Hyperglycemia and Oxidative Stress Normalizes Endothelial Function in Type 1 Diabetes. Ceriello, Antonio; Kumar, Sudhesh; Piconi, Ludovica; Esposito, Katerine; Giugliano, Dario // Diabetes Care;Mar2007, Vol. 30 Issue 3, p649 

    OBJECTIVE -- Previous studies have shown that in type 1 diabetes endothelial dysfunction persists even when glycemia is normalized. Moreover, oxidative stress has recently been demonstrated to be the mediator of hyperglycemia-induced endothelial dysfunction. RESEARCH DESIGN AND METHODS --...

  • Early and intermediate Amadori glycosylation adducts, oxidative stress, and endothelial dysfunction in the streptozotocin-induced diabetic rats vasculature Rodríguez-Mañas et al.: Endothelial dysfunction in diabetes. Rodríguez-Mañas, L.; Angulo, J.; Vallejo, S.; Peiró, C.; Sánchez-Ferrer, A.; Cercas, E.; López-Dóriga, P.; Sánchez-Ferrer, C. F. // Diabetologia;Apr2003, Vol. 46 Issue 4, p556 

    Aims/hypothesis. In a model of streptozotocin-induced Type 1 diabetes mellitus in rats of 9 weeks duration, we analysed time associations between the development of hyperglycaemia, early and intermediate glycosylation Amadori adducts, or AGE compared with enhancement of oxidative stress and...

  • Hyperglycemia and hyperlipidemia are associated with endothelial dysfunction during the development of type 2 diabetes. Okon, Elena B.; Chung, Ada W.Y.; Zhang, Hongbin; Laher, Ismail; van Breemen, Cornelis // Canadian Journal of Physiology & Pharmacology;May2007, Vol. 85 Issue 5, p562 

    Diabetes mellitus impairs endothelial function, which can be considered as the hallmark in the development of cardiovascular diseases. Hyperglycemia, hyperinsulinemia, and hyperlipidemia are believed to contribute to endothelial dysfunction. In the present study, we investigated the possible...

  • Fundamentals in diabetes. Part 1: An introduction to vascular complications. Lockman, Khalida Ann; Ritchie, Stuart Alexander; Adamson, Karen Ann // Journal of Diabetes Nursing;2011, Vol. 15 Issue 9, p256 

    Macro- and microvascular complications can result in significant morbidity and mortality in people with diabetes. Hence the condition poses an enormous challenge to the healthcare system. The synergistic effect of hyperglycaemia and other risk factors have been directly linked with the...


    Provides information on a study about the susceptibility of brain and pancreatic endothelial cells to carbonyl stress-induced apoptosis to be presented at the 65th Scientific Sessions of the American Diabetes Association at the San Diego Convention Center in California from June 10 to 14, 2005. ...

  • MicroRNA-146a Decreases High Glucose/Thrombin-Induced Endothelial Inflammation by Inhibiting NAPDH Oxidase 4 Expression. Huang-Joe Wang; Yuan-Li Huang; Ya-Yun Shih; Hsing-Yu Wu; Ching-Tien Peng; Wan-Yu Lo // Mediators of Inflammation;2014, Vol. 2014, p1 

    Diabetes is associated with hyperglycemia and increased thrombin production. However, it is unknown whether a combination of high glucose and thrombin can modulate the expression of NAPDH oxidase (Nox) subtypes in human aortic endothelial cells (HAECs).Moreover, we investigated the role of a...

  • Dicarbonyl Stress and Atherosclerosis: Is It All RAGE? Muniyappa, Ranganath; Srinivas, Pothur R. // Diabetes;Nov2014, Vol. 63 Issue 11, p3587 

    The article discusses the study "Dicarbonyl Stress in the Absence of Hyperglycemia Increases Endothelial Inflammation and Atherogenesis Similar to That Observed in Diabetes" by C. Tikellis, R. J. Pickering, D. Tsorotes and colleagues, published within the issue. Topics discussed include the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics