TITLE

Na+/H+ exchanger is required for hyperglycaemia-induced endothelial dysfunction via calcium-dependent calpain

AUTHOR(S)
Shuangxi Wang; Qisheng Peng; Junhua Zhang; Liying Liu
PUB. DATE
November 2008
SOURCE
Cardiovascular Research;Nov2008, Vol. 80 Issue 2, p255
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Aims: Recent studies have reported that the calcium-dependent protease calpain is involved in hyperglycaemia-induced endothelial dysfunction and that the Na+/H+ exchanger (NHE) is responsible for an increase in the intracellular calcium (Ca2+i) concentration in diabetes. We hypothesized that activation of NHE mediates hyperglycaemia-induced endothelial dysfunction via calcium-dependent calpain.
ACCESSION #
44394573

 

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