The molecular regulation of GADD153 in apoptosis of cultured vascular smooth muscle cells by cyclic mechanical stretch

Wen-Pin Cheng; Huei-Fong Hung; Bao-Wei Wang; Kou-Gi Shyu
February 2008
Cardiovascular Research;Feb2008, Vol. 77 Issue 3, p551
Academic Journal
Aims: The expression of GADD153 (growth arrest and DNA damage-inducible gene 153), an apoptosis-regulated gene, increases during endoplasmic reticulum (ER) stress. How mechanical stretch affects the regulation of GADD153 in vascular smooth muscle cells (VSMCs) during apoptosis is not fully understood. We aimed to test the hypothesis that mechanical stretch induces GADD153 expression in VSMCs undergoing apoptosis.


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