Mohapatra, S.; Xess, I.; Swetha, J. V.; Tanveer, N.; Asati, D.; Ramam, M.; Singh, M. K.
October 2009
Indian Journal of Medical Microbiology;Oct2009, Vol. 27 Issue 4, p367
Academic Journal
Primary cutaneous aspergillosis is a rare entity, usually caused by A. fumigatus and A. flavus. Here, we present such a case, manifested by ulceration due to A. niger, which remained undiagnosed for a prolonged period. The immunological status was intact, although the patient had associated severe fungal infection. Recurrence of the lesion occurred despite repeated anti-fungal therapies. Anti fungal testing was done based on the broth dilution (M-38A, NCCLS, USA) method. The culture isolate was found to be sensitive to fluconazole and amphotericin B. Continuation of antifungal therapy improved the symptoms, reducing the size of the lesion.


Related Articles

  • Amphotericin B liposomal.  // Reactions Weekly;1/26/2008, Issue 1186, p8 

    The article describes the case of four patients who developed hyperphosphataemia during treatment with amphotericin B liposomal for invasive mycoses. An 11-year-old boy, who had Aspergillosis fumigatis, received amphotericin B liposomal and developed hyperphosphataemia, which led to drug...

  • Experimental Pulmonary Aspergillosis Due to Aspergillus terreus: Pathogenesis and Treatment of an Emerging Fungal Pathogen Resistant to Amphotericin B. Walsh, Thomas J.; Petraitis, Vidmantas; Petraitiene, Ruta; Field-Ridley, Aida; Sutton, Deanna; Ghannoum, Mahmoud; Sein, Tin; Schaufele, robert; Peter, Joanne; Bacher, John; Casler, Heather; Armstrong, derek; Espinel-Ingroff, Anna; Rinaldi, Michael G.; Lyman, Caronh A. // Journal of Infectious Diseases;7/15/2003, Vol. 188 Issue 2, p305 

    Aspergillus terreus is an uncommon but emerging fungal pathogen, which causes lethal infections that are often refractory to amphotericin B (AmB). In comparison to Aspergillus fumigatus, A. terreus was resistant to the in vitro fungicidal effects of safely achievable concentrations of AmB. These...

  • Aspergillus niger: an unusual cause of invasive pulmonary aspergillosis. Person, A. K.; Chudgar, S. M.; Norton, B. L. // Journal of Invasive Fungal Infections;2010, Vol. 4 Issue 4, p148 

    The case of a 72-year-old female diagnosed with pulmonary infection secondary to Aspergillus niger that did not respond to voriconazole therapy is presented in this article.

  • Treatment of murine systemic aspergillosis with polyene-intralipid admixtures. Sionov, Edward; Segal, Esther // Medical Mycology;Feb2004, Vol. 42 Issue 1, p73 

    The objective of this research was the evaluation of the activity of admixtures of amphotericin B (AMB) - intralipid (AMB-IL) and nystatin (Ny) - intralipid (Ny-IL) against experimental systemic aspergillosis in immunocompromised mice. ICR mice were transiently immunosuppressed by...

  • Aspergillosis in the CLEAR outcomes trial: working toward a real-world clinical perspective. Kleinberg, M. // Medical Mycology;Feb2005 Supplement 1, Vol. 43, p289 

    Aspergillosis is a potentially lethal infection of immunocompromised patients. Until 10 years ago, antifungal therapy was largely limited to amphotericin B deoxycholate. Perceived poor response rates and inherent toxicities with amphotericin B deoxycholate were a major stimulus for the...

  • Primary Cutaneous Aspergillosis. Nakashirna, Keiko; Yamada, Nanako; Yoshida, Yuichi; Yamamoto, Osamu // Acta Dermato-Venereologica;2010, Vol. 90 Issue 5, p519 

    The article presents a case study of a 66-year-old Japanese woman with an asymptomatic nodule on the tip of her right thumb. Histopathology revealed a massive epidermal necrosis and dermal necrobiosis. She was diagnosed with primary cutaneous aspergillosis caused by Aspergillus (A.) flavus. The...

  • Voriconazole dominates liposomal amphotericin B in aspergillosis.  // PharmacoEconomics & Outcomes News;12/3/2005, Issue 492, p8 

    The article presents information on a study which found that voriconazole is cost effective than liposomal amphotericin B in patients with probable or proven invasive aspergillosis in Great Britain. The results of the study was presented at the 8th Annual European Congress of the International...

  • Emericella quadrilineata as Cause of Invasive Aspergillosis. Verweij, Paul E.; Varga, J├ínos; Houbraken, Jos; Rijs, Antonius J.M.M.; VerduynLunel, Frans M.; Blijlevens, Nicole M.A.; Shea, Yvonne R.; Holland, Steven M.; Warris, Adilia; Melchers, Willem J. G.; Samson, Robert A. // Emerging Infectious Diseases;Apr2008, Vol. 14 Issue 4, p566 

    We noted a cluster of 4 cases of infection or colonization by Emericella spp., identified by sequence-based analysis as E. quadrilineata. Sequence-based analysis of an international collection of 33 Emericella isolates identified 12 as E. nidulans, all 12 of which had previously been identified...

  • Two Cases of Cerebral Aspergillosis Successfully Treated with Voriconazole. de Lastours, V.; Lefort, A.; Zappa, M.; Dufour, V.; Belmatoug, N.; Fantin, B. // European Journal of Clinical Microbiology & Infectious Diseases;May2003, Vol. 22 Issue 5, p297 

    Described here are two cases of cerebral aspergillosis successfully treated with voriconazole after the failure of first-line treatment with amphotericin B deoxycholate. In both cases, clinical and radiological cure was achieved within 6 weeks. Voriconazole should be considered as first-line...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics