Pharmacokinetic interaction of some antitubercular drugs with caraway: implications in the enhancement of drug bioavailability

Sachin, B. S.; P. Monica; Sharma, S. C.; Satti, N. K.; Tikoo, M. K.; Tikoo, A. K.; Suri, K. A.; Gupta, B. D.; Johri, R. K.
April 2009
Human & Experimental Toxicology;Apr2009, Vol. 28 Issue 4, p175
Academic Journal
This study deals with the pharmacokinetic interaction of selected anti-TB drugs with a natural product (CC-1a) derived from caraway (Carum carvi, L.) seed. CC-1a, chemically standardized butanolic fraction, enhanced the plasma levels of rifampicin, pyrazinamide, and isoniazid in Wistar rat, resulting in increased bioavailability indices (Cmax and AUC) of the drugs. Moreover, a 40% reduced dose regimen of these drugs, which additionally contained CC-1a, was equivalent in terms of Cmax and AUC to a normal dose regimen. A permeationenhancing property of CC-1a across small intestinal absorptive surface was found to be a contributing factor in its bioavailability enhancing profile.


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