TITLE

Biphasic Kill Curve of Isoniazid Reveals the Presence of Drug-Tolerant, Not Drug-Resistant, Mycobacterium tuberculosis in the Guinea Pig

AUTHOR(S)
Spector, Stephen A.
PUB. DATE
October 2009
SOURCE
Journal of Infectious Diseases;10/1/2009, Vol. 200 Issue 7, p1136
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article presents a research study on the anti tuberculosis (TB) activity of isoniazid and its ability to select for drug-resistant mutant strains in guinea pigs, in which the histopathology of TB closely resembles that of human TB. In this study, researchers developed a guinea pig model of TB chemotherapy in which the peak M. tuberculosis burden approaches that observed in human pulmonary cavities to test the bactericidal activity of isoniazid and its ability to select for drugresistant mutants.
ACCESSION #
44249953

 

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