TITLE

HIV Type 1 Infection in Women: Increased Transcription of HIV Type 1 in Ectocervical Tissue Explants

AUTHOR(S)
Asin, Susana N.; Eszterhas, Susan K.; Rollenhagen, Christiane; Heimberg, Alysha M.; Howell, Alexandra L.
PUB. DATE
September 2009
SOURCE
Journal of Infectious Diseases;9/15/2009, Vol. 200 Issue 6, p965
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background. Mucosal surfaces of the female reproductive tract are the main routes of heterosexual transmission of human immunodeficiency virus type 1 (HIV-1), but the contribution of each of the reproductive sites to mucosal transmission is unknown. Methods. We compared levels of HIV-1 transcription between ectocervical and endometrial tissue explants infected ex vivo with HIV-1. Results. We detected higher levels of HIV-1 transcription in the ectocervix. Although CD45 expression was also increased at this site, higher levels of HIV-1 transcription could not be accounted for exclusively by differences in CD45 expression. This suggests that factors other than CD45 levels regulate HIV-1 transcription within the ectocervix. We detected higher levels of interleukin (IL)-6 at this site. Furthermore, addition of recombinant IL- 6 to tissue explants enhanced HIV-1 transcription to a much greater degree in the ectocervix than in the endometrium. Conclusions. This is, to our knowledge, the first study to compare ectocervix and endometrium in a tissue explant model of HIV-1 infection and to demonstrate greater HIV-1 transcription in the ectocervix. Our results suggest that the ectocervix is more conducive to HIV-1 replication than is the endometrium and that IL-6 enhances HIV-1 transcription at this site. Thus, the ectocervix is an important site to be considered in heterosexual transmission of HIV-1.
ACCESSION #
44249933

 

Related Articles

  • HIV-associated eosinophilic folliculitis in a Chinese woman: a case report and a survey in Hong Kong. Ho, M. H.; Chong, L. Y.; Ho, T. T. Y.; Ho, T T // International Journal of STD & AIDS;Aug1998, Vol. 9 Issue 8, p489 

    This is the first survey of eosinophilic folliculitis (EF) in patients infected with the human immunodeficiency virus (HIV) in Hong Kong. The present report provides the local data on HIV-associated eosinophilic folliculitis (HIV-EF) and includes the first Chinese, heterosexual female patient...

  • "It is her responsibility": partner involvement in prevention of mother to child transmission of HIV programmes, northern Tanzania. Falnes, Eli Fjeld; Moland, Karen Marie; Tylleskär, Thorkild; Paoli, Marina Manuela de; Msuya, Sia E.; Engebretsen, Ingunn M. S. // Journal of the International AIDS Society;2011, Vol. 14 Issue 1, p1 

    Background: Partner involvement has been deemed fundamental in prevention of mother to child transmission (PMTCT) programmes, but is difficult to achieve. This study aimed to explore acceptability of the PMTCT programme components and to identify structural and cultural challenges to male...

  • Viral Dynamics of Primary HIV-1 Infection in Senegal, West Africa. Dieng Sarr, Abdoulaye; Eisen, Geoffrey; Guèye-Ndiaye, Aïssatou; Mullins, Christopher; Traoré, Ibraliima; Ciré Dia, Mamadou; Sankalé, Jean-Louis; Faye, Diegane; Mboup, Souleymane; Kanki, Phyllis // Journal of Infectious Diseases;5/1/2005, Vol. 191 Issue 9, p1460 

    Background. Few studies have addressed primary human immunodeficiency virus (HIV) type 1 infection in sub-Saharan Africa, where the epidemic is of a predominantly heterosexual character and is caused by different subtypes. The present study examines the dynamics of viral replication in subjects...

  • Progressive hypertrophic genital herpes in an HIV-infected woman despite immune recovery on antiretroviral therapy. Yudin, Mark H.; Kaul, Rupert // Infectious Diseases in Obstetrics & Gynecology;2008, Vol. 2008, Special section p1 

    Most HIV-infected individuals are coinfected by Herpes simplex virus type 2 (HSV-2). HSV-2 reactivates more frequently in HIV-coinfected individuals with advanced immunosuppression, and may have very unusual clinical presentations, including hypertrophic genital lesions. We report the case of a...

  • Mucosal gatekeepers: Selecting HIV viruses for early infection. Bomsel, Morgane; David, Violaine // Nature Medicine;Feb2002, Vol. 8 Issue 2, p114 

    Focuses on a study that shows that mucosal cells are the principal portal of HIV-1 entry. Description of a new model system by researchers Smith and colleagues to study the initial events of HIV-1 entry in monostratified epithelium; Occurrence of a selection process at the site of the HIV-1 entry.

  • Preliminary assessment of breastfeeding practices in HIV 1-infected mothers (prior to weaning) under the Djoungolo programme on the prevention of mother-to-child transmission of HIV. Nlend, Anne Esther Njom; Ekani, Bernadette Bagfegue // Journal of Tropical Pediatrics;Dec2010, Vol. 56 Issue 6, p436 

    Background: Human Immunodeficiency virus (HIV) transmission in a breastfeeding population varies from 20% to 45%. Objective: To evaluate breastfeeding practices and the early basic HIV transmission rate in HIV-exposed children in the Djoungolo health district (prevention of mother-to-child...

  • Effect of post-partum HIV treatment discontinuation.  // Infectious Disease Alert;Jan2009, Vol. 28 Issue 4, p47 

    The article discusses research on the effect of post-partum human immunodeficiency virus (HIV) treatment discontinuation on long-term maternal outcome. It references a study by N. F. Onen et al published in a 2008 issue of the "Journal of the International Association of Physicians AIDS Care."...

  • VACUNAS MUCOSAS PARA PRODUCIR INMUNIDAD CELULAR CONTRA LA INFECCIÓN POR EL VIH Y OTRAS INFECCIONES VÍRICAS. A. Berzofsky, Jay; M. Belyakov, Igor // Vacunas: Prevención de enfermedades y protección de la salud;2004, p245 

    The article presents information on the design of new mucosal vaccines to induce cellular immunity against diseases like AIDS and other viral diseases. Vaccines have been proven to be effective primarily against viruses causing acute, self-limited infections among the most cost-effective...

  • Women & HIV.  // National Women's Health Report;Jun2006, Vol. 28 Issue 2, p1 

    The article discusses issues and other information about HIV in women in the U.S. The early epidemic of HIV/AIDS infection is diagnosed for relatively few women and female adolescent. The leading cause of death for African American women aged 25-34 years is associated with AIDS. Women suffer the...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics