TITLE

Diffusion tensor imaging may help the determination of time at onset in cerebral ischaemia

AUTHOR(S)
Sakai, K.; Yamada, K.; Nagakane, Y.; Mori, S.; Nakagawa, M.; Nishimura, T.
PUB. DATE
September 2009
SOURCE
Journal of Neurology, Neurosurgery & Psychiatry;Sep2009, Vol. 80 Issue 9, p986
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
BACKGROUND AND AIM: The apparent diffusion coefficient (ADC) and anisotropy (eg, fractional anisotropy (FA)) of ischaemic tissue evolve over time. A reduction in diffusivity (ie, λ2and λ3) is an important marker for characterising hyperacute-stage infarction, as these parameters may reflect axonal membrane status. The study examines whether transverse diffusivity could be useful in assessing white matter infarcts of various ages. METHODS: Diffusion tensor imaging data from 44 adult patients (34 men, 10 women, aged 46 to 89 years, mean = 70.3) with acute white matter infarction (1–168 h) of the internal capsule were analysed. Relative eigenvalues were calculated as: (λipsi–λcontra)/λcontra. Lesions were classified based on theoretically expected evolution of diffusivity over time as follows: stage I, FA higher than the contralesional region of interest (ROI); stage II, diffusivity lower than the contralesional side for all eigenvalues; stage III, one of two transverse eigenvalues (λ2or λ3) higher than the contralesional ROI. RESULTS: Stage I infarcts (n = 5) were found primarily within 24 h of the onset of symptoms, with one case found on the third day. Stage II infarcts were found most commonly within 24 h (n = 18), and fewer after 24 h. After the first day, the ratio of stage III infarcts increased significantly. Thus, diffusivity-based classification of white matter infarcts seems to show a chronological trend. CONCLUSIONS: Diffusion anisotropy may be useful for defining the biological tissue clock of white matter infarctions.
ACCESSION #
44221183

 

Related Articles

  • Diffusion tensor imaging applications in multiple sclerosis patients using 3T magnetic resonance: a preliminary study. Testaverde, Lorenzo; Caporali, Laura; Venditti, Eugenio; Grillea, Giovanni; Colonnese, Claudio // European Radiology;May2012, Vol. 22 Issue 5, p990 

    Objectives: This study evaluated patients with multiple sclerosis using diffusion tensor imaging (DTI) to obtain fractional anisotropy (FA) and mean diffusivity (MD) values. Methods: We investigated the possible statistically significant variation of MD and FA in different MS patients, compared...

  • Diffusion tensor imaging and voxel based morphometry study in amyotrophic lateral sclerosis: relationships with motor disability. Thivard, Lionel; Pradat, Pierre-François; Lehéricy, Stéphane; Lacomblez, Lucette; Dormont, Didier; Chiras, Jacques; Benali, Habib; Meininger, Vincent // Journal of Neurology, Neurosurgery & Psychiatry;Aug2007, Vol. 78 Issue 8, p889 

    The aim of this study was to investigate the extent of cortical and subcortical lesions in amyotrophic lateral sclerosis (ALS) using, in combination, voxel based diffusion tensor imaging (DTI) and voxel based morphometry (VBM). We included 15 patients with definite or probable ALS and 25 healthy...

  • Brain macro- and microscopic damage in patients with paediatric MS. Martina Absinta // Journal of Neurology, Neurosurgery & Psychiatry;Dec2010, Vol. 81 Issue 12, p1357 

    OBJECTIVE: To characterise, using conventional and diffusion tensor (DT) MRI, the nature and distribution of lesions and the extent of damage in the brain normal-appearing white matter (NAWM) and grey matter (GM) from a relatively large population of paediatric multiple sclerosis (MS) patients....

  • What Does Diffusion Tensor Imaging Reveal About the Brain and Cognition in Fetal Alcohol Spectrum Disorders? Wozniak, Jeffrey R.; Muetzel, Ryan L. // Neuropsychology Review;Jun2011, Vol. 21 Issue 2, p133 

    Over the past 5 years, Diffusion Tensor Imaging (DTI) has begun to provide new evidence about the effects of prenatal alcohol exposure on white matter development. DTI, which examines microstructural tissue integrity, is sensitive to more subtle white matter abnormalities than traditional...

  • Research on the Image Segmentation and Classification based on the Diffusion Tensor algorithm. Li Hua // International Journal of Digital Content Technology & its Applic;Jan2012, Vol. 6 Issue 1, p319 

    Diffusion tensor imaging which measures the diffusion characteristics of water molecules in the brain, is an important technique for inferring the structure of the white matter tracts. However, DTI data is often underexploited in current techniques for segmentation and classification of these...

  • White Matter Development in Early Puberty: A Longitudinal Volumetric and Diffusion Tensor Imaging Twin Study. Brouwer, Rachel M.; Mandl, René C. W.; Schnack, Hugo G.; van Soelen, Inge L. C.; van Baal, G. Caroline; Peper, Jiska S.; Kahn, René S.; Boomsma, Dorret I.; Pol, H. E. Hulshoff // PLoS ONE;Apr2012, Vol. 7 Issue 4, p1 

    White matter microstructure and volume show synchronous developmental patterns in children. White matter volume increases considerably during development. Fractional anisotropy, a measure for white matter microstructural directionality, also increases with age. Development of white matter volume...

  • DTI reveals network injury in perinatal stroke. Dudink, Jeroen; Counsell, Serena J.; Lequin, Maarten H.; Govaert, Paul P. // Archives of Disease in Childhood -- Fetal & Neonatal Edition;Sep2012, Vol. 97 Issue 5, pF362 

    Background Previous research showed acute diffusion-weighted imaging changes in pulvinar after extensive cortical injury from neonatal stroke. The authors used diffusion tensor imaging (DTI) to see how separate regions of ipsilateral thalamus are directly affected after a primary hit to their...

  • Usefulness of diffusion tensor imaging and fiber tractography in neurological and neurosurgical pediatric diseases. Spalice, Alberto; Nicita, Francesco; Papetti, Laura; Ursitti, Fabiana; Di Biasi, Claudio; Parisi, Pasquale; Ruggieri, Martino; Iannetti, Paola // Child's Nervous System;Aug2010, Vol. 26 Issue 8, p995 

    Diffusion tensor imaging (DTI) with fiber tractography (FT) is a recently introduced imaging technique that is unique in providing detailed imaging of white matter (WM) tracts and connectivity between different regions of the brain not easily appreciated with other imaging methods. DTI has been...

  • White matter abnormalities in patients with focal cortical dysplasia revealed by diffusion tensor imaging analysis in a voxelwise approach. Carvalho Fonseca, Viviane de; Yasuda, Clarissa Lin; Tedeschi, Guilherme Garlipp; Betting, Luiz Eduardo; Cendes, Fernando // Frontiers in Neurology;Jul2012, Vol. 3, p1 

    Background: Diffusion tensor imaging (DTI) allows the analysis of changes in microstructure, through the quantification of the spread and direction of water molecules in tissues. We used fractional anisotropy (FA) maps to compare the integrity of WM between patients and controls. The objective...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics