Miniaturized tools and devices for bioanalytical applications: an overview

Chudy, Michal; Grabowska, Ilona; Ciosek, Patrycja; Filipowicz-Szymanska, Alicja; Stadnik, Dorota; Wyzkiewicz, Iwona; Jedrych, Elzbieta; Juchniewicz, Marcin; Skolimowski, Maciej; Ziolkowska, Karina; Kwapiszewski, Radoslaw
October 2009
Analytical & Bioanalytical Chemistry;Oct2009, Vol. 395 Issue 3, p647
Academic Journal
This article presents an overview of various miniaturized devices and technologies developed by our group. Innovative, fast and cheap procedures for the fabrication of laboratory microsystems based on commercially available materials are reported and compared with well-established microfabrication techniques. The modules fabricated and tested in our laboratory can be used independently or they can be set up in different configurations to form functional measurement systems. We also report further applications of the presented modules e.g. disposable poly(dimethylsiloxane) (PDMS) microcuvettes, fibre optic detectors, potentiometric sensors platforms, microreactors and capillary electrophoresis (CE) microchips as well as integrated microsystems e.g. double detection microanalytical systems, devices for studying enzymatic reactions and a microsystem for cell culture and lysis.


Related Articles

  • Design and performance of a high-resolution frictional force microscope with quantitative three-dimensional force sensitivity. Dienwiebel, M.; de Kuyper, E.; Crama, L.; Frenken, J. W. M.; Heimberg, J. A.; Spaanderman, D.-J.; van Loon, D. Glastra; Zijlstra, T.; van der Drift, E. // Review of Scientific Instruments;Apr2005, Vol. 76 Issue 4, p043704 

    In this article, the construction and initial tests of a frictional force microscope are described. The instrument makes use of a microfabricated cantilever that allows one to independently measure the lateral forces in X and Y directions as well as the normal force. We use four fiber-optic...

  • Trends in computational simulations of electrochemical processes under hydrodynamic flow in microchannels. Santillo, Michael F.; Ewing, Andrew G.; Heien, Michael L. // Analytical & Bioanalytical Chemistry;Jan2011, Vol. 399 Issue 1, p183 

    Computational modeling and theoretical simulations have recently become important tools for the development, characterization, and validation of microfluidic devices. The recent proliferation of commercial user-friendly software has allowed researchers in the microfluidics community, who might...

  • A capillary electrophoresis chip with hydrodynamic sample injection for measurements from a continuous sample flow. BĆ¼ttgenbach, S.; Wilke, R. // Analytical & Bioanalytical Chemistry;Nov2005, Vol. 383 Issue 5, p733 

    A microchip-based capillary electrophoresis device supported by a microfluidic network made of poly(dimethylsiloxane), used for measuring target analytes from a continuous sample flow, is presented. The microsystem was fabricated by means of replica molding in combination with standard...

  • Design and Fabrication of Fiber-Optic Nanoprobes for Optical Sensing. Zhang, Yan; Dhawan, Anuj; Vo-Dinh, Tuan // Nanoscale Research Letters;Jan2011, Vol. 6 Issue 1, p1 

    This paper describes the design and fabrication of fiber-optic nanoprobes developed for optical detection in single living cells. It is critical to fabricate probes with well-controlled nanoapertures for optimized spatial resolution and optical transmission. The detection sensitivity of...

  • Measure hot spots with light. Blackburn, Steve // Electrical World;Jul/Aug2000, Vol. 214 Issue 4, p64 

    Focuses on the use of fiberoptic temperature sensors in measuring hot spots. Mechanism of action of the sensors; Probe design; Role of the source spectrum.

  • Fiberoptic sensors monitor environmental conditions. Lerner, Eric J. // Laser Focus World;Sep97, Vol. 33 Issue 9, p107 

    Focuses on fiberoptic sensors. Differences between intrinsic and hybrid sensors; Outline of the sensors' mechanism of action through the use of internal reflection and evanescence; Applications of Bragg gratings for enhancing sensitivity of sensors; Usage of interferometers in sensitivity...

  • Fiber-optic Displacement Sensor Using Multimode Plastic Fiber Probe and Tooth Surface. Rahman, H. A.; Harun, S. W.; Batumalay, M.; Muttalib, F. A. // Fiber Optic Sensors & Systems;Jan2013, Vol. 27 Issue 1, p13 

    The article discusses research published in the January 2013 issue of "Sensors Journal," on the performances of a fiber-optic displacement sensor on a tooth surface.

  • Multiplexed fiber gratings enhance mechanical sensing. Miller, Calvin; Li, Tom; Miller, Jeff; Bao, Faye; Hsu, Kevin // Laser Focus World;Mar98, Vol. 34 Issue 3, p119 

    Focuses on fiber Bragg gratings (FBGs), a fiberoptic device used for dense wavelength division demultiplexing, dispersion compensation, laser stabilization and erbium-doped amplifier gain flattening. Usage as optical fiber sensors; Creation of a multiwavelength-referenced FBG interrogation...

  • Fluorescent-based lifetime measurement thermometer for use at subroom temperatures (200--300 K). Anghel, F.; Iliescu, C.; Grattan, K.T.V.; Palmer, A.W. // Review of Scientific Instruments;Mar95, Vol. 66 Issue 3, p2611 

    Describes the development, construction and evaluation of a simple ruby-based fiber optic thermometer for use over the region 200-300 K. Comparison of results with those obtained from a simple theoretical model; Discussion of the application of such a sensor to the food processing industry and...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics