Severe hypoxia induces chemo-resistance in clinical cervical tumors through MVP over-expression

January 2009
Radiation Oncology;2009, Vol. 4, p29
Academic Journal
No abstract available.


Related Articles

  • SIRT1 expression enhanced antitumor effect of Cisplatin decreased by chronic hypoxia in human non-small cell lung cancer. Shin, D. // Proceedings of the Physiological Society;2013, p337P 

    Hypoxia induced drug resistance is a major obstacle in the development of effective cancer therapy. Hypoxia is also associated with human non-small cell lung cancer (NSCLC), which is highly resistant to chemotherapy. However, the exact mechanisms driving hypoxia induced chemoresistance of NSCLC...

  • Knockdown of glucose-regulated protein 78 abrogates chemoresistance of hypopharyngeal carcinoma cells to cisplatin induced by unfolded protein in response to severe hypoxia. LIHONG PI; XIAOMING LI; QI SONG; YUPENG SHEN; XIUYING LU; BIN DI // Oncology Letters;2014, Vol. 7 Issue 3, p685 

    Hypoxia renders tumor cells with reduced sensitivity and increased resistance to chemotherapeutic agents. One of the possible mechanisms underlying this unfavorable status is activation of the unfolded protein response (UPR) under hypoxic conditions, due to the upregulation of glucose-regulated...

  • Metadherin confers chemoresistance of cervical cancer cells by inducing autophagy and activating ERK/NF-κB pathway. Zhang, Jingwei; Zhang, Yunyan; Liu, Shuang; Zhang, Qingmeng; Wang, Yan; Tong, Liping; Chen, Xiaohang; Ji, Yuting; Shang, Qinglong; Xu, Baozhan; Chu, Ming; Wei, Lanlan // Tumor Biology;Aug2013, Vol. 34 Issue 4, p2433 

    Overexpression of metadherin (MTDH) has been reported in many solid tumors and implicated in chemoresistance. This study aimed to examine MTDH expression in cervical cancer tissues and explore its role in chemoresistance of cervical cancer. MTDH expression in cervical cancer biopsies and several...

  • ATF4, an ER Stress and Hypoxia-Inducible Transcription Factor and its Potential Role in Hypoxia Tolerance and Tumorigenesis. Jiangbin Ye; Koumenis, Constantinos // Current Molecular Medicine;May2009, Vol. 9 Issue 4, p411 

    Hypoxia/anoxia promotes tumor aggressiveness and negatively impacts tumor response to therapy. Coordinate regulation of HIF-dependent and HIF-independent pathways has been shown to contribute to cellular adaptation to hypoxic stress, and to couple macromolecular synthesis rates to reduced energy...

  • Pim-1 plays a pivotal role in hypoxia-induced chemoresistance. Chen, J.; Kobayashi, M.; Darmanin, S.; Qiao, Y.; Gully, C.; Zhao, R.; Yeung, S. C.; Lee, M. H. // Oncogene;7/16/2009, Vol. 28 Issue 28, p2581 

    Hypoxia changes the responses of cancer cells to many chemotherapy agents, resulting in chemoresistance. The underlying molecular mechanism of hypoxia-induced drug resistance remains unclear. Pim-1 is a survival kinase, which phosphorylates Bad at serine 112 to antagonize drug-induced apoptosis....

  • Autophagy inhibits chemotherapy-induced apoptosis through downregulating Bad and Bim in hepatocellular carcinoma cells. Yan Zhou; Kai Sun; Yi Ma; Haozheng Yang; Yuanliang Zhang; Xianming Kong; Lixin Wei // Scientific Reports;6/20/2014, p1 

    The tumor microenvironment, including ischemia, has been increasingly recognized as a critical factor in the process of tumor development. Hypoxia and nutrient deficiency resulting from ischemia widely exist in solid tumors. Recent studies have shown that hypoxia and nutrient deficiency...

  • HIF-1 is involved in the negative regulation of AURKA expression in breast cancer cell lines under hypoxic conditions. Fanale, Daniele; Bazan, Viviana; Corsini, Lidia; Caruso, Stefano; Insalaco, Lavinia; Castiglia, Marta; Cicero, Giuseppe; Bronte, Giuseppe; Russo, Antonio // Breast Cancer Research & Treatment;Aug2013, Vol. 140 Issue 3, p505 

    Numerous microarray-based gene expression studies performed on several types of solid tumors revealed significant changes in key genes involved in progression and regulation of the cell cycle, including AURKA that is known to be overexpressed in many types of human malignancies. Tumor hypoxia is...

  • HIF-1 as a Target for Cancer Chemotherapy, Chemosensitization and Chemoprevention. Monti, Elena; Gariboldi, Marzia B. // Current Molecular Pharmacology;Jan2011, Vol. 4 Issue 1, p62 

    Cells in rapidly growing solid tumors are commonly exposed to chronic or intermittent hypoxia. Hypoxia can induce cell death by multiple mechanisms; however, some cells may adapt by orchestrating dramatic changes in gene expression patterns. In addition, hypoxia exerts a powerful selective...

  • HER2 Expression Beyond Breast Cancer: Therapeutic Implications for Gynecologic Malignancies. English, Diana; Roque, Dana; Santin, Alessandro // Molecular Diagnosis & Therapy;Apr2013, Vol. 17 Issue 2, p85 

    HER2 or ErbB2 is a member of the epidermal growth factor family and is overexpressed in subsets of breast, ovarian, gastric, colorectal, pancreatic, and endometrial cancers. HER2 regulates signaling through several pathways (Ras/Raf/mitogen-activated protein kinase and phosphatidylinositol-3...

  • HIF-1-mediated activation of telomerase in cervical cancer cells. Yatabe, Noriyuki; Kyo, Satoru; Maida, Yoshiko; Nishi, Hirotaka; Nakamura, Mitsuhiro; Kanaya, Taro; Tanaka, Masaaki; Tsaka, Keiichi; Ogawa, Satoshi; Inoue, Masaki // Oncogene;4/29/2004, Vol. 23 Issue 20, p3708 

    Hypoxia-inducible factor 1 (HIF-1) is a key regulator of O2 homeostasis, which regulates the expression of several genes linked to angiogenesis and energy metabolism. Tumor hypoxia has been shown to be associated with poor prognosis in a variety of tumors, and HIF-1 induced by hypoxia plays...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics